儿科门诊600例手足口病患儿用药疗效的评价

Evaluation of therapeutic efficacy of 600 cases of children with hand foot and mouth disease in outpatient department of Pediatrics

目的探讨儿科门诊600例手足口病患儿用药情况,并对用药疗效和安全性进行评价。方法选取该院2011年1月—2013年12月儿科门诊治疗的600例手足口病患儿为研究对象,根据用药不同分为治疗组和对照组,治疗组采用喜炎平注射液,对照组采用利巴韦林治疗,观察两组的疗效并对其进行安全性评价,疗效观察比较两组在退热时间、皮疹消退时间,口腔症状缓解时间及转为重症病例上是否存在差异。结果通过统计分析,治疗组在退热时间、皮疹消退时间,口腔症状缓解时间上明显短于对照组,差异有统计学意义(P<0.05);治疗组在转重症率上明显低于对照组,差异有统计学意义(P<0.05)。结论采用喜炎平注射液治疗手足口病疗效优于利巴韦林,安全性上未发现严重不良反应,具有应用价值。

Objective To study the pediatric outpatient service 600 cases of children with hand, foot and mouth disease medica-tions, and to evaluate the clinical efficacy and safety. Methods Our hospital between Jan 2011 and Dec 2013 pediatric outpatient treatment of 600 cases of children with hand, foot and mouth disease as the research object, according to different drugs can be di-vided into the treatment group and control group, treatment group with xi ping injection, control group using ribavirin therapy, to observe the curative effect of two groups and safety evaluation of curative effect observation to compare two groups in the deferves-cence time,time fades, oral symptoms time and whether differences on severe cases. Results Through statistical analysis,the treat-ment group in antifebrile time, time fades, oral symptoms time significantly shorter than the control group, the obvious differences （P〈0.05）; On the transfer rate of severe treatment group was obviously lower than the control group, the obvious differences （P〈0.05）. Conclusion Based on xi phlogistic flat curative effect is better than that of ribavirin injection treatment of hand,foot and mouth disease, found no serious adverse reactions on security, has application value.