长春新碱联合甲基泼尼松龙治疗系统性红斑狼疮并血小板减少症39例疗效探讨

Fludarabine and Cyclophamide Combined With Rituximab Efficacy of the Treatment of Chronic

目的探讨长春新碱联合甲基泼尼松龙治疗系统性红斑狼疮并血小板减少症的疗效,为临床治疗提供依据。方法选取系统性红斑狼疮并血小板减少症患者78例,随机分为对照组和治疗组各39例,对照组应用甲基泼尼松龙大剂量冲击治疗,治疗组应用长春新碱联合甲基泼尼松龙治疗,进行疗效比较观察。结果治疗组CR25例(64.10%),PR 10例(25.64%),NR 4例(10.26%),总有效率(CR+PR)89.74%;对照组CR19例(48.72%),PR 7例(17.95%),NR 13例(33.33%),总有效率(CR+PR)66.66%。两组数据比较,总有效率(CR+PR)x^2检验,x^2为3.343,P=0.032,*P<0.05,说明经统计学处理差异有显著性。结论 应用长春新碱联合甲基泼尼松龙治疗系统性红斑狼疮并血小板减少症,不仅可以提高治疗效果,减少出血,而且可以改善和提高患者的生活质量,值得临床推广应用。

O bjective Discussion the effect of vincristine and methyl prednisolone treatment of systemic lupus erythematosus and thrombocytopenia , provide the basis for clinical treatment. Methods Selected 78 patients with systemic lupus erythematosus and thrombocytopenia, were randomly divided into a control group and the treatment group , 39 patients in the control group with high-dose methylprednisolone pulse therapy , treatment group and methyl prednisolone, vincristine, efficacy comparison observation. Results CR 25 cases treatment group （64.10%）, PR 10 cases （25.64%）, NR 4 cases （10.26%）, the total effective rate （CR＋PR） 89.74%. CR19cases control group （48.72%）, PR 7 cases（17.95%）, NR 13 cases（33.33%）, the total effective rate （CR＋PR）66.66%. Compare two sets of data , the total efficiency（CR＋PR） chi-square test ,χ2=3.343, P=0.032,＊P〈0.05, explain differences were sta-tistically significant. Conclusion vincristine and methyl prednisolone treatment of Systemic lupus erythematosus and thrombocy-topenia , not only can improve the therapeutic effect and reduce Bleeding, and can improve and enhance the quality of life of pa-tients , worthy of clinical application.