FGF19与多囊卵巢综合征相关性研究

Study on the Correlation Between PCOS and FGF19

多囊卵巢综合征(PCOS)是一种在育龄期妇女中比较常见的内分泌紊乱性疾病。PCOS与生殖系统及代谢紊乱有关,具有肥胖、血脂异常、胰岛素抵抗等心血管疾病(CVD)的高危因素,其远期CVD风险增高。成纤维细胞生长因子19(FGF19)是新近发现的能够调节糖脂代谢、胆汁酸代谢,提高能量代谢,调节胆囊充盈等的内分泌激素。FGF19可能通过调节糖脂代谢逆转高脂肪饮食(HFD)引起的体重增加、肝脏脂肪堆积、胰岛素抵抗和血脂水平的增加等。推测FGF19可通过调节糖脂代谢降低体重、血脂水平及改善葡萄糖利用、胰岛素敏感性等在PCOS发生发展中起着一定的作用,为PCOS提供一种新的治疗靶点,本文就此做一综述。

Polycystic ovary syndrome （PCOS） is a relatively common endocrine disorder among women of reproductive age a. PCOS is associated with reproductive and metabolic disturbances. PCOS women were at substantial risks for development of glucose intolerance, diabetes, lipid abnormalities and cardiovascular abnormalities since they often had insulin resistance. Fibroblast growth factor 19 （FGF19 ）can regulate glucose, lipid metabolism and reverses high fat diet （HFD）-induced weight gain, hepatic lipid accumulation, insulin resistance, and increased serum lipid levels.It suggests that FGF19 may plays an important role in regulating glucose and lipid metabolism,reduce the body weight, serumlipid level and improve the utilization of glucose,insulin sensitivityin the occurrence and development of PCOS,this article makes a summary on this.