小剂量尿激酶在急性心肌梗塞溶栓治疗中的疗效分析

Effect Observation of Small Dose Urokinase in Treatment of Thrombolytic Therapy of Acute Myocardial Infarction

目的小剂量尿激酶在心肌梗死溶栓治疗中的疗效分析。方法选取2012年7月—2014年4月该院收治的急性心肌梗塞患者75例,并分为常规组(n=38)和小剂量组(n=37)。常规组给予150U尿激酶治疗,小剂量组给予50U尿激酶治疗,比较两组的溶栓再通率、急性期死亡率和溶栓不良反应。结果常规组溶栓总再通率为84.21%,显著高于小剂量组45.94%(x^2=12.119,P=0.000);常规治疗组的急性期死亡率为2.63%,显著低于小剂量组33.33%(x^2=4.730,P=0.030)。常规剂量组,溶栓治疗后不良发生率为18.42%,小剂量组则为18.91%,两组比较,差异无统计学意义(x^2=0.003,P=0.956)。结论在急性心肌梗塞溶栓治疗中,需给予足量的尿激酶,小剂量的治疗效果不甚理想。

Objective To investigate effect of small dose urokinase in treatment of thrombolytic therapy of acute myocardial infarction.Methods 75 patients from 2012 July to 2014 April in our hospital were selected,and were divided into two groups.The routine group was given 150U urokinase,while small dose group was given 50U urokinase.Thrombolytic recanalization rate, acute mortality and adverse reaction rate of two groups were compared.Results Thrombolysis total recanalization rate of routine group was 84.21%,which was significantly higher than the small dose group（45.94%）（c2=12.119,P=0.000）. Thrombolysis total recanalization rate of routine group was 2.63%,which was significantly lower than that of the small dose group（18.91%） （c2=4.730,P=0.030）. The adverse reaction rate of routine group was 18.42%,while routine group was 18.91%,and there was no significant difference between two groups（c2=0.003,P=0.956）.Conclusion In the thrombolytic therapy of acute myocardial infarction treatment, enough small dose urokinase should be given, and treatment effect of small dose of urokinase is not very ideal.