阿仑膦酸钠维D_3与阿仑膦酸钠治疗骨质疏松症的效果对比

Alendronate Sodium and Vitamin D_3 and the Effect of Treatment of Osteoporosis Alendronate Contrast

目的对比阿仑膦酸钠维D_3与阿仑膦酸钠治疗骨质疏松症的效果。方法选取84例骨质疏松症患者,随机均分成两组。治疗组和对照组患者分别口服阿仑膦酸钠维D_3片和阿仑膦酸钠片,各70 mg/周;同时两组患者均口服钙剂600mg/d;连续治疗6个月。观察治疗前后患者骨密度、骨转换指标β-Crosslaps和TP1NP变化以及临床效果。结果治疗后,对照组患者骨密度明显升高,但治疗组升高更显著(P<0.05);对照组患者血清β-Crosslaps、TP1NP均有下降,但治疗组两者下降更显著(P<0.05);对照组患者总有效率76.19%,明显低于治疗组92.86%(P<0.05);两组患者未见明显不良反应。结论两种药物治疗骨质疏松症均安全有效,但阿仑膦酸钠维D_3疗效更好。

Objective Bi Alun alendronate and vitamin D3 treatment with alendronate for osteoporosis results.Methods 84 cases of patients with osteoporosis were randomly divided into two groups. Treatment group and control group patients were oral alendronate and vitamin D3 tablets and alendronate tablets, each 70 mg / week; while patients were oral calcium 600 mg / d; continuous treatment for six months.Observed in patients with bone mineral density,bone turnover markers β-Crosslaps and TP1NP changes and clinical effects after treatment.Results After treatment, patients in the control group significantly increased bone mineral density,but the treatment group increased more significantly （P〈0.05）; control group, serum β-Crosslaps,TP1NP were decreased, but both the treatment group decreased more significantly （P〈0.05）; the total efficiency of the control group were 76.19%, significantly lower than the treatment group, 92.86% （P〈0.05）; the two groups were no significant adverse reactions.Conclusion Of the two drugs to treat osteoporosis are safe and effective, but better efficacy of alendronate and vitamin D3.