胺碘酮对合并有室性早搏的老年无症状心肌缺血患者QTd的影响研究

Study of Amiodarone for Merging More than 60 Years Old with Ventricular Premature Beat Patients with Asymptomatic Myocardial Ischemia of QTd

目的探讨胺碘酮对合并有室性早搏的老年无症状心肌缺血患者QTd的影响。方法收集该院心内科2012年12月—2014年10月收治的共计100例大于60岁无症状心肌缺血患者作为研究对象。按随机数字表法分为2组,胺碘酮组50例和硝酸异山梨酯组50例。胺碘酮组口服盐酸胺碘酮片,硝酸异山梨酯组口服单硝酸异山梨酯片,两组治疗疗程均为8周。比较:①治疗前、治疗后胺碘酮组与硝酸异山梨酯组QTd;②治疗前和治疗后使用动态心电图监测两组患者ST段压低次数与ST段压低持续时间。结果治疗前胺碘酮组与硝酸异山梨酯组QTd为(75.6±19.3)、(74.2±20.8),差异无统计学意义(P>0.05);治疗后胺碘酮组与硝酸异山梨酯组QTd为(42.9±14.1)、(49.6±21.2),差异有统计学意义(P<0.05)。治疗前胺碘酮组与硝酸异山梨酯组对ST段压低次数与ST段压低持续时间分别为(216.9±56.8)次、(526.3±165.4)min、(218.2±49.9)次、(539.6±178.6)min,差异无统计学意义(P>0.05);治疗后胺碘酮组与硝酸异山梨酯组对ST段压低次数与ST段压低持续时间分别为(74.2±12.4)次、(95.6±18.5)min、(145.9±36.4)次、139.8±54.7)min,差异有统计学意义(P<0.05)(t=0.003、0.001、0.002,P<0.05)。结论该研究认为胺碘酮较硝酸酯类更能改善伴有室性早搏老年无症状心肌缺血患者的QTd,减少无症状心肌缺血发作次数与无症状心肌缺血持续时间。

Objective To study the amiodarone of merger in elderly patients with asymptomatic myocardial ischemia with ventricular premature beat the influence of QTd.Methods collectted our heart between 2012.12 and 2012.10 with a total of 100 cases of asymptomatic myocardial ischemia was greater than 60 patients as the research object. Divided into 2 groups according to random number table method, amiodarone group of 50 cases with different yamanashi nitrate ester group of 50 cases.Amiodarone group oral amiodarone hydrochloride tablets, different yamanashi nitrate ester group oral isosorbide mononitrate, two groups of treatment were 8 weeks.①before and after treatment amiodarone group with different yamanashi nitrate ester group QTd; ②before and after treatment with dynamic electrocardiogram （ecg） monitoring of two groups of patients with ST segment down times and ST segment down last time. Results before treatment of amiodarone group with different yamanashi nitrate ester group QTd was（75.6±19.3）、（74.2±20.8）mm, there was no statistically significant difference （P〉 0.05）; After treatment of amiodarone group with different yamanashi nitrate ester group QTd was（42.9±14.1）、（49.6±21.2）, the difference was statistically significant （P 〈 0.05）. Before treatment of amiodarone group with different yamanashi nitrate ester group of ST segment down times and ST segment down duration respectively （216.9±56.8）次、（526.3±165.4）min、（218.2±649.8）次、（539.6±178.6）min, there was no statistically significant difference （P 〉 0.05）; After treatment of amiodarone group with different yamanashi nitrate ester group of ST segment down times and ST segment down duration respectively （74.2±12.4）次、（95.6±18.5）min、（145.9±36.4）次、（139.8±54.7）min, the difference was statistically significant （P 〈 0.05）.Conclusion We thinks that amiodarone is nitric acid ester can improve more than 60 patients with ventricular premature beat QTd with asymptomatic myocardial ischemia, reducing asymptomatic myocardial ischemia attack frequency and duration of asymptomatic myocardial ischemia.