淋巴瘤临床治疗现状的文献分析

Analysis of Clinical Research Literature on Randomized Controlled China Lymphoma Treatment

目的对我国淋巴瘤治疗的文献展开分析,探讨不同治疗方案的具体效果。方法对1989—2014年之间中国知网、万方数据库中淋巴瘤治疗文献展开分析。结果所有120篇淋巴瘤治疗文献共涉及期刊79种,霍奇金淋巴瘤患者为研究对象的1篇,另外112篇均以非霍奇金淋巴瘤患者为观察对象。淋巴瘤以男性多发,发病年龄多在60岁以上。17篇文献718例CHOP化疗有效率达到70%以上。15篇文献中氨甲喋呤为基础的联合化疗治疗的缓解率达到80%以上。全脑放疗63篇文献共2 472例患者均证明具有较好的局部控制效果。结论全脑化疗与CHOP放疗以及氨甲喋呤基础化疗均有较好的效果,淋巴瘤临床研究的主要侧重经济落后地区以及中西部偏远地区。

Objective Analysis of literature on China’s lymphoma treatment expansion, to investigate the specific effects of different treatment regimens. Method To analyze the lymphoma between 1989 and 2014, Wan Fang China HowNet database treatment literature. Results All the 120 article lymphoma therapy literature involving a total of 79 kinds of periodicals, Hodgkin lymphoma patients as the research object of the 1 articles, 112 articles were also in non Hodgkin lymphoma patients as the observation object. Lymphoma occurs mainly in men, age at onset of more than 60 years old. Lymphoma, multiple male, age over 60 years of age. 17 documents 718 cases of CHOP chemotherapy efficiency of more than 70%. 15 response rates in the literature methotrexate-based combination chemotherapy in the treatment of more than 80%. WBRT total of 2 472 cases of 63 patients literature proved better local control.Conclusion CHOP chemotherapy and whole brain radiotherapy and methotrexate-based chemotherapy have better results, lymphoma clinical studies focused mainly on economically backward regions and remote central and western regions.