摘要
目的研究不同剂量盐酸替罗非班联合PCI治疗老年急性冠脉综合征合并糖尿病患者的临床疗效以及安全性,为临床治疗提供可参考依据。方法选取该院201 2年1月—2014年1月内科收治急性冠脉综合征合并糖尿病老年患者153例,按照自愿原则分为3组,每组51例。对照组使用低分子肝素钙,半量组使用低分子肝素钙联合半量盐酸替罗非班;全量组使用低分子肝素钙联合全量盐酸替罗非班。统计三组各项观察指标。结果全量组的出血发生率(27.45%)显著高于对照组(3.92%)和半量组(5.88%);全量组发生率(9.8%)显著低于对照组发生率(64.71%),差异具有统计学意义(P<0.05)。结论使用盐酸替罗非班联合冠状动脉介入治疗老年急性冠脉综合征合并糖尿病,能够有效抗凝、抗血栓形成,使用半量盐酸替罗非班安全性高,可以在临床治疗中推广使用。
ObjectiveTo study on efficacy and safety the different dose of tirofiban therapy combined with PCIsyndrome complicated with diabetes clinical therapeutic of elderly acute coronary, provides the reference for the clinical treatment of.Methods 153 cases with acute coronary syndrome complicated with diabetes in elderly patients in our hospital from January 2012 to January 2014 were admitted, according to the principles of voluntary, divided into 3 groups, 51 cases in each group. The control group used low molecular weight heparin, half dose groups using low molecular weight heparin calcium combined with half dose of tirofiban hydrochloride; total group using low molecular weight heparin calcium combined with full dose tirofiban hydrochloride. Statistical the observation index of three groups.Results The incidence rate of the bleeding total group (27.45%) was significantly higher than that of the control group (3.92%) and half dose group (5.88%); the full amount. The incidence rate of the bleeding total group (9.8%) was significantly lower than that of the control group (64.71%), the differences were statistically significant (P〈0.05).Conclusion the use of tirofiban combined coronary artery interventional therapy of elderly patients with acute coronary syndrome complicated with diabetes, can effective anticoagulant, anti thrombosis,the use of half dose of tirofiban hydrochloride and high safety, can be widely used in clinical treatment.
出处
《中外医疗》
2015年第11期114-115,共2页
China & Foreign Medical Treatment
关键词
盐酸替罗非班
老年急性冠脉综合征
糖尿病
PCI
Tirofiban hydrochloride
PCI
Acute coronary syndrome
Diabetes mellitus