羟基磷灰石对硼酸盐生物活性玻璃降解性能的调控

Influence of Hydroxyapatite on the Degradation Performance of Borate Bioactive Glass

将熔融法制备的硼酸盐生物玻璃按不同比率与羟基磷灰石混合烧结,制备出双相材料支架样品。将各组样品浸泡在生理模拟液中(5 g样品/100 m L浸泡液),置于37℃恒温条件下,进行体外生物矿化反应,考察了支架的降解性能随羟基磷灰石含量的变化情况。实验中,通过ICP测试,研究了硼元素在支架降解过程中的释放情况。通过XRD和FTIR分析了产生变化的原因,结果表明硼酸盐生物活性玻璃与羟基磷灰石在600℃混合烧结后会产生新的晶相,使得结构更加稳定,降解速度放缓,尤其克服了B元素在降解初期的过量释放。

The composite scaffold samples were prepared with mixed sintering method by using borate bioactive glass prepared by melting method and different content ratio of Hydroxyapatite （HAP） as composing. Each samples was soaked in the fluid of the simulated body fluid （SBF, 5 g sample/100 mL） at constant temperature of 37 ℃ for bio-mineralization reaction. The degradation property of composite scaffolds with different content ratio of HAP was analyzed. In this article, the released of Boron ions in the degradation process was characterized through ICP-AES. The XRD and FTIR results indicated that new phase appeared in the process of sintering borate bioactive glass and Hydroxyapatite at 600 ℃, which enable the structure more stable and the speed of biodegradation slower. Especially, the excessive release of Boron ions in the early was overcame.