温胆汤联合帕罗西汀应用于焦虑障碍治疗初期临床研究

Clinical Study of Wendan Decoction Combining with Paroxe tine on the Early Treatment of Anxiety Disorder

目的观察温胆汤应用于焦虑障碍治疗初期的临床疗效。方法将106例焦虑障碍患者随机分为2组。治疗组57例患者以温胆汤联合帕罗西丁治疗,对照组49例患者予帕罗西丁联合劳拉西泮治疗,2组均21 d为1个疗程,1个疗程后采用Hanmilton焦虑量表(HAM A)、焦虑自评量表(SAS)、匹兹堡睡眠量表(PSQI)评分统计疗效。结果治疗组总有效率96.43%,对照组总有效率90.00%,2组比较差异有统计学意义(P<0.05)。治疗组治疗前后HAM A、SAS、PSQI改善明显(P<0.05),优于对照组。结论温胆汤应用于焦虑障碍治疗初期有效。

Objective To observe the effect of wendan decoction combining with Paroxetine on the esrly treatment of anxiety disorder. Me thods 106 cases of anxiety disorder w ere randomly divided into control group,w hich w as treated by Paroxetine combining w ith（ Lora Zepam）,and treatment group,w hich w as treated by Wendan decoction combining w ith Paroxetine. The course w as 21 days in tw o groups. The therapeutic effect w as evaluated by HAM A score,SAS score and PSQI score after one courses. Re sults The total effective rate in treatment group（ 96.43%） w as higher than that in control group（ 90.00% P〈0.05）.The score of HAM A,SAS and PSQI after treatment w as significantly improved as compared w ith that before treatment in treatment group（ P〈0.05）. The improment in treatment group w as superior to that in control group after treatment（ P〈0.05）. Conclusion Wendan decoction w as effective for the early treatment of anxiety disorder.