基于Web of Science的罕用药文献计量分析

Bibliometric analysis of literature on orphan drug in the Web of Science

目的 :从文献计量学的角度分析20多年来罕用药研究的发展状况。方法 :利用Science Citation Index Expanded引文数据库检索1992-2014年间罕用药研究的文献,分别从罕用药研究的国家、机构、作者的发文量、被引频次、期刊分布及研究方向等进行统计分析。结果 :1992-2014年间共有罕用药文献2 050篇,分布于250种期刊,近10年来文献量逐渐增多,主要研究方向是药理学、生物化学分子生物学、肿瘤学、神经科学神经病学、化学、细胞生物学等。美国、英国、法国、瑞士等国在该领域内影响力大。结论 :罕见病日益引起人们的关注,美国、欧盟等发达国家在罕用药研究领域占有绝对优势,中国还处在起步阶段,应进一步提高对此项研究的投入和研究水平。

Objective： To analyze the status of research on orphan drug from 1992 to 2014 using a bibliometric approach. Methods： Literature on orphan drug from the Web of Science＇s Science Citation Index Expanded database was searched. The search results were analyzed with regard to the number of articles, frequency of citations by country, institution and author, journal of publication, and fields covered by the article. Results： In total 2 050 articles related to orphan drug were published in 250 journals from 1992 to 2014, covering pharmacology, biochemistry, molecular biology, oncology, neuroscience, neurology, chemistry, cell biology, etc. The number of papers has increased apparently over the last 10 years. The United States, Britain, France, Switzerland have played important roles in the orphan drug research in the world. Conclusion： Rare disease has attracted more and more attention. US, EU and other developed countries play a leading role in research on orphan drug. China is still in her infancy, we should improve the level of investment and research on orphan drug.