Toll样受体4介导急性心肌梗死后炎症反应的研究进展被引量：4

Advances of Toll-like Receptor 4 on Inflammatory Reaction after Acute Myocardial Infarction

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摘要心肌坏死后持续的炎症反应是导致急性心肌梗死(AMI)后心室重构(VR)的关键病理环节,其中Toll样受体(TLR)4介导的炎症信号途径在AMI后VR中的关键作用越来越受到关注。目前,关于TLR4介导的自身炎症反应特点研究的比较多,关于TLR4介导的AMI后炎症反应的基础和临床研究仍在进行中。其介导的炎症信号途径在AMI后的启动时间、高表达时间、维持时间及最佳药物干预时间等尚不明确,需要今后不断的深入研究将其一一阐释。 Persistent inflammation is the key pathological circle on ventricular remodeling （ VR） after acute myocardial infarction（AMI）,and more and more attention is paid to the role of Toll-like receptor 4 （TLR4） on VR after AMI.At present,it′s known that a lot about the inflammation reaction of TLR4, but the study on the inflammation reaction of TLR4 after AMI is still in progress.The start time, the peak time and the maintenance time of TLR4 on inflammatory reaction after AMI are still unclear , which need further research.

作者董国菊李立志

机构地区中国中医科学院西苑医院心血管科

出处《医学综述》 2015年第10期1735-1737,共3页 Medical Recapitulate

基金国家自然科学青年科学基金(81001517) 国家自然科学基金面上项目(81273929)

关键词急性心肌梗死 TOLL样受体4 炎症反应 Acute myocardial infarction Toll-like receptor 4 Inflammatory reaction

分类号 R542.22 [医药卫生—心血管疾病]

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