硫辛酸对糖尿病及其慢性并发症的作用机制研究进展

Research Progress on the Effects and Mechanism of Lipoic Acid against Diabetes and Chronic Diabetic Complications

糖尿病及糖尿病肾病患病率的快速增长,给家庭及社会造成了极大的负担。由于缺乏有效的治疗方法,目前临床上只能防止糖尿病肾病的发生、进展,或肾脏替代治疗。硫辛酸具有强大的抗氧化效应,并通过下丘脑及外周组织腺苷酸活化蛋白激酶(AMPK)信号通路调节机体能量代谢,因而对糖尿病及其慢性并发症发挥保护作用。硫辛酸可通过增强组织细胞AMPK活性进而抑制雷帕霉素靶蛋白信号通路,对细胞生长和蛋白质合成发挥调节作用。该文就硫辛酸对糖尿病及其慢性并发症的作用机制研究进展予以综述。

Rapid growth of diabetes and diabetic kidney disease exerts a great burden on family and society.Due to the lack of effective treatments for diabetic kidney disease,treatment relies on drugs that either reduces its progression or involves renal replacement therapies.Lipoic acid is a powerful antioxidant,which can regulate energy metabolism via adenosine 5′-monophosphate-activated protein kinase （ AMPK） signaling in hypothalamus and peripheral tissues.Thus,lipoic acid has protective effects against diabetes and chronic diabetic complications by these diverse actions.Recently, lipoic acid has been shown to suppress mammalian target of rapamycin signaling in various tissues and cells by activating AMPK , thereby regulates cell growth and protein synthesis.Here is to make a review of the role and mechanisms of lipoic acid against diabetes and diabetic chronic complications.