Wnt经典通路对2型糖尿病β细胞功能的调控进展被引量：2

Progression of Research on Canonical Wnt / β-catenin Signaling Pathway on the Modulation of β Cell Function in Type 2 Diabetes

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摘要胰岛β细胞功能受损是2型糖尿病发病的重要基础。多项研究发现提示,Wnt/β联蛋白经典信号通路通过直接或者与胰高血糖素样肽1、炎症通路等相互作用的方式对胰岛β细胞的新生、增殖及其功能发挥重要的调控作用,且可能介导了外周组织与β细胞的对话机制。对该通路及其调节分子在胰岛β细胞中的作用机制的深入探讨有助于为2型糖尿病的治疗提供新的思路和方向。 Islet βcell dysfunction is the fundamental factor in the pathogenesis of type 2 diabetes.Multi-ple researches have implicated that the canonical Wnt/β-catenin signaling pathway may have significant effect on islet βcell neogenesis, proliferation and its function by direct or indirect interaction with glucagon-like peptide or inflammatory pathway.Also this pathway might possibly mediate the cross-talk betweenβcell and peripheral tissues.The in-depth research on canonical Wnt/β-catenin signaling pathway and its modula-tors′effect on the function of islet βcells can provide new directions for type 2 diabetes therapy.

作者代喆徐焱成

机构地区武汉大学中南医院内分泌科

出处《医学综述》 2015年第10期1831-1833,共3页 Medical Recapitulate

基金国家自然基金面上项目(81370872) 湖北省卫生厅青年科技人才项目(QJX2010-20)

关键词 2型糖尿病 Β细胞 Wnt/β联蛋白经典信号通路 Type 2 diabetes β cell Canonical Wnt/β-catenin signaling pathway

分类号 R587.1 [医药卫生—内分泌]

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