甲状腺微小癌复发情况及其影响因素分析

Study on the Recurrence and Influence Factors of Thyroid Microcarcinoma

目的探究临床淋巴结阴性c N0甲状腺微小癌的复发情况及其影响因素。方法采用自编问卷收集2008年6月至2011年6月深圳市宝安区西乡人民医院甲状腺外科收治的375例c N0甲状腺微小癌患者的临床资料,通过门诊、电话、QQ和飞信等方式完成为期3年的随访,采用描述性统计和二分类Logistic回归分析进行临床资料的分析。结果甲状腺微小癌复发率为14.4%。二分类Logistic回归分析显示,甲状腺包膜侵犯(回归系数为1.95,OR=7.03)、中央区淋巴结未清除(回归系数为2.61,OR=0.07)和术后未接受放射性碘治疗(回归系数为2.01,OR=0.13)是患者复发的危险因素。结论甲状腺微小癌术后复发仍较高,其复发受多方面因素影响。如果条件允许,中央区淋巴结清除并让患者术后接受放射性碘治疗能降低患者术后复发率。

Objective To analyze the recurrence and influence factors of lymph node negative cN0 thy-roid microcarcinoma.Methods Clinical data of 375 cases of cN0 thyroid microcarcinoma treated in Xixiang People′s Hospital of Baoan District from Jun.2008 to Jun.2011 were collected by the self-made question-naire.A three-year follow-up were completed via outpatient,QQ,telephone and fetion services.The conclu-sion were analyzed by descriptive statistics and classified logistic regression analysis .Results The recur-rence rate of thyroid microcarcinoma was 14.4%.Logistic regression analysis found that the thyroid capsular invasion（regression coefficient=1.95,OR =7.03）,not remove lymph node in central region（regression coefficient=2.61,OR=0.13） and postoperative not receive radioactive iodine therapy（regression coeffi-cient=2.01,OR=0.07） were the risk factors of the recurrence.Conclusion The postoperative recurrence rate of thyroid microcarcinoma is still high,the recurrence is influenced by many factors.If the conditions per-mit,removing lymph node in central region and applying postoperative radioactive iodine therapy can reduce recurrence probability.