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肿瘤干细胞可塑性的研究进展

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摘要 肿瘤干细胞的可塑性是指肿瘤干细胞在一定的条件下分化成为不同功能性肿瘤细胞的能力。比如肿瘤干细胞可以通过EMT分化成不同生物学特性的细胞,如果选取一时间点观察,在同一细胞亚群中包含着不同分化去向的细胞,即异质性,从时间的纵向观察,细胞在分裂增殖的过程中也存在着分化现象,即同一特性的细胞可能分化成不同的细胞,即可塑性。这就提醒研究者对于肿瘤干细胞的研究不能采取静态的观察方法 ,应该将其放到原有的环境中动态地观察其特征。
出处 《广东医学》 CAS 北大核心 2015年第9期1454-1456,共3页 Guangdong Medical Journal
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