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腹膜假性粘液瘤减瘤术复合术中热灌注化疗的长时间麻醉管理模式探讨 被引量:1

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摘要 目的观察腹膜假性粘液瘤减瘤术复合术中热灌注化疗的长时间麻醉分段管理的临床效果。方法 84例患者静脉诱导后随机分为A、B两组:A组麻醉维持采用全凭静脉麻醉。B组麻醉维持分3个阶段:第一阶段,热灌注化疗前,单纯静脉全麻;第二阶段,热灌注化疗全程,单纯吸入全麻;第三阶段,热灌注后,静吸复合麻醉。BIS控制在40∽60之间。分别于插管前、后(T0、T1),放腹水前、后(T2、T3),热灌注前、后(T4、T5)观察并记录气道压,血糖、收缩压、心率、CVP、血气变化。统计手术和出入量。结果两组患者性别、年龄、体重、手术时间和种类的差异无显著性意义(P〉0.05)。气道压、血糖、心率、收缩压、p H及BE在T5时两组差异有显著性意义(P〈0.05)。A、B两组患者术毕在手术室内拔管分别为29(69%)、41(98%),两组间差异有显著性意义(P〈0.05)。结论腹膜假性粘液瘤减瘤术复合术中热灌注化疗的长时间麻醉维持分段管理模式能有效的减少麻醉药物蓄积,有助于术毕拔管;分段麻醉管理模式有利于维持酸碱平衡及电解质正常;全吸入麻醉在腹腔热灌注化疗中优于全凭静脉麻醉。
出处 《海峡药学》 2015年第5期180-181,共2页 Strait Pharmaceutical Journal
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