滋肾平肝经验方辨治肝阳上亢型高血压临床研究

Research on Treating Hyperactivity of Liver Yang Syndrome Hypertensive Patients with Nourishing Kidney and Calming the Liver Decoction

目的：探讨用滋肾平肝经验方治疗肝阳上亢型高血压患者的临床效果。方法：选择2012年7月—2014年10月就诊于我院的肝阳上亢型高血压患者136例为研究对象,将患者按照随机数字表法分为对照组和治疗组患者各68例。对照组患者单纯给予尼群地平片治疗;治疗组患者则在对照组治疗的基础上给予滋肾平肝经验汤剂内服治疗,1剂/d,1周为1个疗程,连续治疗8个疗程。治疗后测量血压观察两组患者血压的改善情况;观察主要临床症状的改善情况,并对证候轻重进行0-3分的评分,观察评分变化情况;监测治疗前后的血流变化,计算临床治疗的有效率。结果：对照组患者的有效率为76.4%,治疗组患者的有效率为92.6%,治疗组的有效率明显高于对照组,差异有统计学意义（P〈0.05）;两组患者的收缩压、舒张压经治疗后均有所降低,且趋于稳定,治疗组患者血压的降低幅度更为明显,差异有统计学意义（P〈0.05）;两组患者治疗后眩晕、头痛、面红目赤、急躁易怒、口干口苦、便秘等临床症状有所改善,证候积分较治疗前有所下降,以治疗组患者的降低幅度明显大于对照组患者,差异有统计学意义（P〈0.05）;治疗组患者的血液流变改善情况明显好于对照组患者,差异有统计学意义（P〈0.05）。结论：滋肾平肝经验方能有效缓解肝阳上亢型高血压患者的临床症状,降低患者血压水平,改善患者的血液流变,疗效显著,值得临床深入研究运用。

Objective： To investigate the clinical efficacy of treating hyperactivity of liver yang syndrome hypertensive patients with nourishing kidney and calming the liver decoction. Methods： 136 hypertensive patients were randomLy divided into a control group of 68 cases and a treatment group of 68 cases from July 2012 to October 2014. Patients in the control group were treated with nitrendipine tablets; while patients in the treatment group were primarily treated with nourishingkidney and calming the liver decoction, 1 agent/day, oneweek for treatment, 8 courses for treatment. Before and after treatment, we observed the improvement of blood pressure andthe main clinical symptoms. We evaluated the symptoms with 0 to 3 scores according to the difference of degree, and observed the change of scores. We tested the blood flow changes, and calculated the effective rate of the two groups. Results ： The efficiency for patients in the control group is 76.4%, while for patients in the treatment group is 92.6%.The clinical efficacy of the treatment group was higher than that of the control group, the difference is significant （P〈0.05）; The systolic pressure and diastolic pressure went down compared with before treatment and tended to stable, the degree of change in the treatment group was more pronounced, the difference is significant （ P〈0.05 ）;the main clinical symptoms of the patients in two groups, such as dizziness, headache, flushing, hot eyes, impatience, dry mouth, constipation, were improved clearly, and the symptom scores went down clearly, the degree of change in the treatment group was more pronounced, the difference is significant （P〈0.05）; the blood flow changes of the patients in the treatment was better than that of the control group, the difference is significant （ P〈0.05 ）. Conclusion ： Treating hyperactivity of liver yang syndrome hypertensive patients with nourishing kidney and calming the liver decoction can relieve the main clinical symptoms, low the level of blood pressure and improve the blood flow changes, which has satisfactory clinical effect, is worthy of further research and development.