禽体内氟苯尼考药动学参数的异速生长分析

Allometric Analysis of Florfenicol Pharmacokinetics Parameters in Five Avian Species

在收集氟苯尼考在5种禽(鹌鹑、鸽、肉鸡、鸭和火鸡)体内药动学参数的基础上,利用异速生长分析法研究了氟苯尼考的3个主要药动学参数(体清除率(Cl)、稳态表观分布容积(Vss)和消除半衰期(t1/2β))与体重之间的关系。使用了传统的幂函数型异速生长方程来描述药动学参数Y与禽体重W之间的关系,即Y=a×Wb,其中a为幂函数的系数,b为幂函数的指数。研究结果显示:Cl、Vss和t1/2β与W之间的关系式分别为Vss=4.017 7×W-0.508、Cl=1.442 7×W-0.811和t1/2β=3.613 3×W-0.042,相关系数则分别为0.682 5、0.862 5和0.008 6。结果表明,利用异速生长分析能够较准确地预测氟苯尼考在禽体内的药动学参数,特别是Vss和Cl。

This study was to analyze the relationship between pharmacokinetics parameters and body weight （W） for florfenicol using previously reported pharmacokinetics parameters. The parameters of interest： clearance （C1）, volume of distribution at steady state （Vss） and half life of elimination （t1/2β） were correla- ted across five avain species, including quail, pigeon, broiler chickens, ducks, and turkeys as a function of W using the conventional allometric equation of Y=a × Wb, where Y is the pharmacokinetics parameter, W is the body weight, a is the allometric coefficient and b is the exponent that describes the relationship between the pharmacokinetics parameter and W. Our estimates （Vss =4. 017 7 × W-0.508, CI= 1. 442 7 × W-0, 811, and t1/2β = 3. 613 3 × W-0.042） indicated that these parameters and W all approximates a linear pow- er relationship with the correlation coefficient （R2） of 0. 682 5, 0. 862 5, and 0. 008 6, respectively. Over- all, the results of this study indicated that it is possible to use allometry analysis to predict pharmacokinet- ies parameters （especially Vss and C1） of florfenicol based on W of avian species.