动物源性葡萄球菌多重耐药基因cfr研究进展

Advance in Multidrug Resistance Gene cfr of Staphylococcus aureus from Animals

葡萄球菌是畜禽化脓性感染、败血症或脓毒败血症的主要病原体,常引起奶牛乳腺炎、禽类葡萄球菌病、羔蜱脓毒症等疾病。由于抗生素的滥用,出现了大量耐药性葡萄球菌,其中携带多重耐药基因cfr的葡萄球菌广泛存在于在畜牧生产中。该类葡萄球菌通过cfr的编码产物作用于核糖体23SrRNA腺苷2503的C8位点,对氯霉素类、林可酰胺类、恶唑烷酮类、截短侧耳素类和链阳菌素A类耐药,为动物疫病防控带来了巨大挑战。论文综述了动物源性葡萄球菌中cfr的分布情况、耐药机制、基因环境及检测技术等方面的研究进展,为深入研究其传播机制、研发新型抗葡萄球菌药物及建立切实有效的cfr多抗预测预警体系提供参考。

Staphylococcus aureus is the main pathogen of pyogenic infection, septicemia or pyosepticemia, and usually cause mastitis in dairy cattle, Staphylococcosis in chickens, tick pyemia and other diseases. Due to the abuse of antibiotics, there has been a lot of resistant Staphylococcus spp. , of which Staphylo- coccus spp. carrying multidrug-resistance cfr gene were widespread in animals. The encoding products of cfr gene mediate multidrug resistance to chloramphenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A by methylating C8 of A2503 in 23S rRNA. In order to provide theoretical basis for further study of transmission mechanism, development of new anti-staphylococcal drugs and establishment of cfr prediction and warning system, the present article reviewed latest advances in distribution, resist- ance mechanism, genetic environment and detection techniques of cfr in animal-derived Staphylococcus au- reus .