犬多发性混合性乳腺瘤的特殊染色鉴别

Differentiation of Multiple Mixed Mastadenoma in Dogs by Special Staining

为了鉴别犬多发性混合性乳腺瘤的形态结构及其发生的关系,用特殊染色法对两例肿瘤进行了详细的病理学观察及分析。结果表明,多发性混合性乳腺瘤组织中除了有单纯性乳腺瘤结构外,还包括乳头状瘤和囊腺瘤的结构,间质中有大量的结缔组织增生,形成条索状的胶原纤维束,增生的结缔化生形成了软骨组织。当乳腺瘤上皮增生过快时,可形成乳腺癌样的组织团块。研究表明,多发性混合性乳腺瘤可继发于单纯性乳腺瘤,是乳腺瘤加重的形态表现;混合性乳腺瘤组织的软骨组织是由结缔组织化生而来。由于多发性混合性乳腺瘤中有多种组织成分不断增生,并可出现乳腺癌样的组织团块,所以该瘤易于发生恶变。

To identify the morphological structure and incidence relationship in multiple mixed mastadenoma of dogs, two tumor cases were observed and analyzed pathologically in detail by special staining. The re- suits revealed that in the tissues of multiple mixed mastadenoma, except for simple mastoncus structure, there were the structures of papilloma and cystadenoma, there were a mass of hyperplastic connective tis- sues in tumor mesenchyme, formed cord-like collagenous fiber and cartilaginous tissue by the metaplasia. Breast cancer-like block masses were examined in tumor tissue when the epithelia of breast tumor were rap- idly growing. In conclusion, multiple mixed mastadenoma might be secondary onset from simple mastade- noma and was an aggravating manifestation. Its cartilaginous tissue came from the metaplasia of connective tissue. Multiple mixed mastadenoma was apt to malignant transformation because there were a lot of con- tinuous proliferative cells and the breast cancer-like tissue masses were found in its tissues.