重庆市男男性行为人群艾滋病患者抗病毒治疗效果分析

Therapeutic effect analysis of MSM after highly active antiretroviral therapy in Chongqing

目的 了解重庆市男男性行为（MSM）人群艾滋病患者抗病毒治疗基本情况,评估不同基线CD4^＋T淋巴细胞数水平的抗病毒治疗效果。方法 在国家艾滋病综合防治信息系统中收集资料,以患者开始治疗时基线CD4^＋T淋巴细胞数水平分类,采用回顾性队列研究方法观察和评估治疗效果,数据运用SPSS18.0软件进行统计分析。结果 1 758例治疗患者平均年龄（33.5±11.1）岁,CD4^＋T〈50个/μL、50~199个/μL、200~350个/μL、〉350个/μL者分别占7.7%、27.6%、54.9%、9.7%,治疗12个月后CD4^＋T值分别维持在150~250个/μL、250~350个/μL、350~450个/μL、450~550个/μL,治疗6个月后病毒载量抑制比例分别为70.2%、81.7%、84.2%、83.3%,治疗36个月生存率分别为0.81、0.93、0.98、1.00。结论 MSM人群艾滋病抗病毒治疗取得显著效果,早期治疗更有利于该人群免疫功能恢复,降低艾滋病病死率,控制疫情。

Objective To know basic characteristics of MSM infected with HIV treated by highly active antiretroviral thera- py（HAART） ,and evaluate therapeutic effect based on the level of CD4^＋ T cell counts. Methods Basic database of patients were collected from the national AIDS comprehensive data information system, patients were observed by the retrospective cohort study, and effect indicators were analyzed based on the level of CD4^＋ T cell counts. The data was analyzed by SPSS18.0 software. Results A total of 1 758 cases were recruited in this study and the average age was （33.5 ± 11.1）years. The component ratio of the CD4^＋ T cell counts 〈50/μL, 50 to 199/μL, 200 to 350/μL, 〉 350/μL were 7.7 % ,27.6 %, 54. 9 %, 9.7%, respectively. The CD4^＋ T counts increased and kept among 150 to 250/μL,250 to 350/μL,350 to 450/μL,450 to 550/μL,respectively after 12 months,treatment. The rates of viral inhibition were 70.2% ,81.7% ,84, 2% ,83.3% ,respectively after 6 monthsr treatment. And the cumulative survival rates were 0.81,0.93,0.98,1.0 after 36, months treatment, respectively. Conclusion HAART on MSM achieves remarkable results. And the early treatment was more beneficial to improve immune function,reduce AIDS mortality and control the HIV/ AIDS epidemic of MSM.