尿液HE4联合CA125检测对卵巢癌的价值分析

Value analysis of urine HE4 combined with serum CA125 for diagnosis of ovarian cancer

目的探讨尿液人附睾上皮分泌蛋白4(HE4)联合血清糖类抗癌抗原125(CA125)检测对卵巢癌的价值。方法选取卵巢良性肿瘤51例、卵巢癌44例患者为研究对象,另选取同期健康体检者50例作为对照组,分析3组受检对象尿液HE4、CA125的水平。结果卵巢癌组HE4及CA125水平均高于良性肿瘤组及对照组,差异均有统计学意义(P<0.05);良性肿瘤组CA125水平高于对照组,差异有统计学意义(P<0.05);良性肿瘤组HE4水平与对照组比较差异无统计学意义(P>0.05)。HE4单独检测对卵巢癌诊断的敏感性、特异性、准确性及阳性率均高于CA 125单独检测,差异有统计学意义(P<0.05);HE 4+CA125联合检测的敏感性、特异性及阳性率均高于HE4及CA125单独检测,差异有统计学意义(P<0.05)。结论 HE4+CA125联合检测可提高卵巢癌的诊断准确性、特异性及敏感性,值得临床推广应用。

Objective To study the value of urine HE4 combined with serum CA125 for the diagn sis of ovarian cancer. Methods A total of 51 patients with ovarian benign tumor and 44 patients with ovarian cancer and 50 cases of healthy controls were chosen for the study. The HE4 and CA125 level of all the cases were determined. Results The HE4 and CA125 of the ovarian cancer patients were higher than those of the ovarian benign tumor patients and healthy controls（P〈 0.05）. The CA125 of the ovarian benign tumor patients were higher than those of the healthy controls（P〈0.05）. There was no difference between the ovarian benign tumor patients than the healthy controls（P〉0.05）. The specificity, sensitivity, accuracy and positive rate of the HE 4 were all higher than those the CA125（P〈0.05）. And the specificity, sensitivity, accuracy and positive rate of the HE4 combined with serum CA125 were all higher than those the CA125 and HE4（all P〈0. 05）. Conclusion The combination of HE4 and serum CA125 can improve the specificity, sensitivity and accuracy in the diagnosis of ovarian cancer.