摘要
目的:评价逍遥散对2型糖尿病兼抑郁症模型大鼠的作用效果。方法:采用高脂饲料喂养加腹腔注射小剂量链脲佐菌素(STZ)的方法制备2型糖尿病模型,在其基础上用21d慢性束缚的方法建立2型糖尿病兼抑郁症大鼠模型。将Wistar大鼠随机分为5组,每组8只:正常组(N组),2型糖尿病组(T组),2型糖尿病兼抑郁症组(T+D组),氟西汀组(F组),逍遥散组(XYS组)。在慢性束缚的21d,从大鼠的宏观表征、体质量、空腹血糖、血清胰岛素及HOMA-IR指数、血脂、旷场行为学实验,评价逍遥散对2型糖尿病兼抑郁症大鼠的作用效果。结果:逍遥散可以增加模型大鼠的体质量,改善大鼠的行为学,降低血脂,通过改善抑郁症状从而降低血糖,改善大鼠胰岛素抵抗。结论:逍遥散对模型大鼠有较好的作用效果,适用于后续研究。
Objective： To evaluate the effects of Xiaoyaosan on the rat model of type 2 diabetes mellitus （T2DM） associated with depression. Methods： The T2DM model rats were induced by high fat diet and low dose of STZ injection, and in addition, the T2DM rats were made restraint stress for 21 days. Wistar rats were randomly divided into five groups： normal group （group N）, T2DM group （group T） and T2DM with depression group （group T＋D）, fluoxetine group （group F） and Xiaoyaosan group （group XYS）, with 8 rats in each group. The effect of Xiaoyaosan on the T2DM rat associated with depression were evaluated by observing the manifestations, measuring the body weight at day 0, 7, 14, and 21, the fasting blood glucose, blood insulin, HOMA IR index, blood lipid, and testing the rat depression by open field test. Results： Xiaoyaosan could increase the body weight, improve the behavior, decrease the blood lipid, and fasting blood glucose by treating depression, improve the insulin resistance. Conclusion： Xiaoyaosan is effective on the rats model of T2DM associated with depression, which is useful for the further relevant studies.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2015年第6期1948-1952,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81072756
No.81473597)
北京中医药大学创新团队项目资助(No.2011CXTD-07)~~
