疏风解毒胶囊治疗社区获得性肺炎临床疗效及对抗生素使用时间的影响

Evaluation on clinical efficacy of Shufeng Jiedu Capsule on community-acquired pneumonia and its influence on therapeutic time of antibiotic

目的:观察疏风解毒胶囊治疗社区获得性肺炎的临床疗效及对抗生素使用时间的影响。方法:将60例社区获得性肺炎患者随机分为治疗组30例、对照组30例,治疗组予基础治疗+疏风解毒胶囊(4粒/次,3次/d口服);对照组予基础治疗。治疗1周后评价两组总疗效、中医症候疗效、中医症候积分和临床肺部感染评分(CPIS),并监测血常规、胸片的变化,同时统计抗生素使用天数和患者的满意度。结果:治疗组与对照组总有效率、中医证候疗效、患者满意度、CPIS比较,差异有统计学意义(P<0.05,P<0.01),治疗组优于对照组。治疗组体温稳定时间,咳嗽、气急、双肺啰音消失天数,平均治愈天数与对照组比较,差异有统计学意义(P<0.05,P<0.01),治疗组优于对照组。治疗后治疗组中医证候部分指标积分,治疗第3天血常规中白细胞(WBC),X线示炎症吸收程度与对照组比较,差异有统计学意义(P<0.05,P<0.01),治疗组优于对照组。治疗组抗生素使用时间少于对照组(P<0.05)。结论:疏风解毒胶囊配合西药常规治疗对社区获得性肺炎疗效肯定,能减少抗生素的使用时间,且安全性好。

Objective： To observe the effects of Shufeng Jiedu capsule on community-acquired pneumonia （CAP） and its influence on therapeutic time of antibiotic. Methods： 60 patients with CAP were randomly divided into treatment group （30 cases） and control group （30 cases）. Patients in treatment group took 4 Shufeng Jiedu Capsules 3 times a day based on the basic treatment, and patients in control group received basic treatment. Overall curative effective, curative effects of TCM syndromes, scores of TCM syndromes, and clinical pulmonary infection scores （CPIS） in both groups were evaluated after one week. Changes in blood routine examination and chest radiography were monitored. Meanwhile, days of antibiotic consumption and patient satisfaction were recorded. Results： Compared with control group, the total effective rate, curative effect of TCM syndromes, patient satisfaction and CPIS of patients in treatment group was significantly better （P〈0.05, P〈0.01）. There were statistically significant differences in duration of body temperature stability, disappearance days of cough, gasp and pulmonary rales, and average days of cure between the two groups （P〈0.05, P〈0.01）, and the curative effect of treatment group was superior to that of control group. There were remarkable differences in scores of TCM syndromes, WBC in blood routine on the third day after treatment, absorption of inflammation shown by X-ray between the two groups, and the curative effect of treatment group was superior to that of control group. Compared with control group, the days of antibiotic consumption of patients in treatment group after the treatment were shortened significantly （P〈0.05）. Conclusion： Shufeng Jiedu Capsule combined with basic treatment was a safe and effective therapy for CAP, and it could reduce the duration of antibiotic consumption.