微量泵泵入利尿合剂对难治性心力衰竭患者B型脑钠肽的影响

The Effect of Diuretic Mixture on Type B Brain Natriuretic Peptide in Patients with Refractory Heart Failure

目的:探讨应用微量泵泵入利尿合剂对难治性心力衰竭患者B型脑钠肽(BNP)的影响。方法:选择2011年1月-2014年1月在本院进行治疗的128例难治性心力衰竭患者作为观察对象,随机数字表法将128例患者分成两组,治疗组与对照组,每组64例,对照组采取常规治疗方法进行治疗,治疗组在常规治疗的基础上应用微量泵泵入利尿合剂,两组患者都以14 d为1个疗程。1个疗程后比较两组患者的BNP水平、平均心率、心率失常发生率及左心室射血分数(LVEF)。结果:两组患者治疗后BNP水平、平均心率、心率失常发生率及LVEF都有所改善,但治疗组的改善程度要高于对照组,比较差异有统计学意义(P<0.01)。结论:微量泵泵入利尿合剂可明显降低难治性心力衰竭患者B型脑钠肽的水平,同时还可改善难治性心力衰竭患者的心功能指标,可在临床中推广应用。

Objective：To explore the effect of diuretic mixture on type B brain natriuretic peptide in patients with refractory heart failure.Method：128 cases with refractory heart failure in our hospital from January 2011 to January 2014 were selected as test objects.128 cases were divided into treatment group and control group,64 cases in each group.The control group was given conventional treatment.The treatment group was given diuretic mixture infused with micro-pump on the basis of conventional treatment.After a course of treatment（14 d）,BNP level,average heart rate,cardiac arrhythmia rate and LVEF were compared.Result：BNP level,average heart rate,cardiac arrhythmia rate and LVEF between the two groups were improved.But the treatment group was better than the control group.The difference was statistically significant （P〈0.01）.Conclusion：Diuretic mixture infused with micro-pump apparently reduces BNP level.Meanwhile,it also improves cardiovascular function.It is worth popularizing application in clinic.