重型颅脑损伤患者血浆8-异前列腺素F2α浓度的检测及临床价值

Clinical significance and prognostic value of plasma 8-iso-Prostaglandin F2α level in patients with severe traumatic brain injury

目的分析血浆8-异前列腺素F2α（8-iso-PGF2α）水平与重型颅脑损伤（STBI）患者外伤严重程度及6个月死亡的关系。方法选取120例STBI患者（外伤组）及120例健康体检者（对照组）作回顾性研究。用酶联免疫吸附试验检测两组血浆8-iso-PGF2α浓度,采用多元线性回归分析法分析其与外伤严重程度的关系。采用受试者工作特征曲线分析血浆8-iso-PGF2α浓度对外伤后6个月死亡的预测价值。结果外伤组血浆8-iso-PGF2α水平高于对照组（t=17.682,P〈0.001）。血浆8-isoPGF2α水平与STBI患者格拉斯哥昏迷评分呈负相关（t=-5.780,P〈0.001）,且是外伤后6个月死亡的独立危险因素（OR=1.007,95%CI=1.004~1.010,P〈0.001）。血浆8-iso-PGF2α水平可预测外伤后6个月死亡（灵敏度：0.82,特异度：0.64,曲线下面积=0.826,95%CI=0.747~0.889）。结论 STBI患者血浆8-iso-PGF2α水平升高,且与其外伤严重度及长期预后密切相关。

Objective To investigate the clinical significance and prognostic value of plasma 8-iso-Prostaglandin F2α（8-iso-PGF2α） level in patents with severe traumatic brain injury （STBI）. Methods A total of 120 patients with STBI （trauma group） and 120 healthy controls （control group） were enrolled in the retrospective study. Plasma 8-iso-PGF2ct concentrations of all the cases were measured by enzyme linked immunosorbent assay. The relationship between the plasma 8-iso-PGF2α level and the trauma severity was analyzed by using multivariate linear regression. The predictive value of 8-iso-PGF2α for 6-month mortality was determined by ROC curve. Results Plasma 8-iso-PGF2α concentrations in the trauma group were substantially higher than those in the control group （t = 17.682, P 〈 0.001）. Plasma 8-iso-PGF2α levels which were inversely related to Glasgow eoma scale scores （t =-5.780, P 〈 0.001）, were also an independent risk factor for 6-month mortality of STBI patients （OR = 1.007, 95%CI = 1.004- 1.010, P 〈 0.001）. Plasma 8-iso-PGF2α level can statistically predict 6-month mortality of STBI patients （sensitivity： 0.82, specificity： 0.64, area under the curve： 0.826, 95%CI = 0.747-0.889）. Conelusions Plasma 8-iso-PGF2α levels were raised in STBI patients. It has a negative correlation with trauma severity, and also affects the long-term mortality in STBI patients.