吡喃阿霉素治疗非霍奇金淋巴瘤的临床效果

Clinical Effect of Non-Hodgkin's Lymphoma Treated by Pirarubicin

目的探讨吡喃阿霉素治疗非霍奇金淋巴瘤的临床效果。方法选择60例初治的非霍奇金淋巴瘤患者,分为观察组和对照组。观察组和对照组分别采用含吡喃阿霉素和阿霉素的方案化疗。评定两组临床效果。观察不良反应发生情况。结果观察组化疗后临床效果评定的总有效率为66.7%;对照组化疗后临床效果评定的总有效率为66.7%;观察组的有效率和对照组有效率比较,差异无统计学意义(P>0.05)。不良反应(白细胞减少、血小板减少、贫血、消化道反应、肝功能损伤、脱发、心电图改变)中观察组在消化道反应、脱发、心电图改变发生率小于对照组,差异有统计学意义(P<0.05)。结论吡喃阿霉素治疗非霍奇金淋巴瘤的临床效果和阿霉素治疗非霍奇金淋巴瘤的临床效果近似,但前者不良反应发生率低于后者,值得临床借鉴。

Objective Explore the clinical effect of pirarubicin in treatment of non Hodgkin＇s lymphoma. Methods 60 cases of initial treatment of non Hodgkin＇s lymphoma patients,divided into observation group and control group. The observation group and the control group respectively by chemotherapy with Tetrahydropyranyl adriamycin and adriamycin. Evaluation of two groups of clinical effect. Observation of adverse reactions occur. Results In the observation group assessment of clinical effect after chemotherapy the total efficiency of 66.7%; control efficacy was evaluated after chemotherapy group the total effective rate was 66.7%; the observation group and the Control group with efficiency efficiency comparison, no significant difference （P〉0.05）. Adverse drug reaction （change the lcukopenia, thrombocytopenia,anemia, gastrointestinal reaction, liver function damage, hair loss, ECG）in the observation group in the digestive tract reaction, hair loss, the change rate of ECG was less than the control group, the difference was statistically significant （P〈0.05）. Conclusion Similar clinical effect of clinical effect and doxorubicin treatment conclusions pirarubicin in treatment of non Hodgkin lymphoma and non Hodgkin＇s lymphoma; but the incidence rate of adverse reaction is lower than that of the latter,worthy of clinical reference.