文拉法辛与帕罗西汀治疗抑郁症的对照研究

Control Study of Venlafaxine and Paroxetine in the Treatment of Depression

目的比较文拉法辛与帕罗西汀治疗抑郁症的临床疗效和不良反应。方法 92例抑郁症患者随机分为文拉法辛组和帕罗西汀组,每组46例,疗程8周。在治疗前及治疗后1、2、4、8周末以汉密尔顿抑郁量表(HAMD)和不良反应量表(TESS)评定疗效与不良反应。结果文拉法辛组显效率和有效率分别为78.26%和91.30%,帕罗西汀组显效率和有效率分别为76.08%和89.13%,两组总体疗效相仿(P>0.05);治疗后两组HAMD评分与治疗前比较均有显著性差异(P<0.01);治疗1周末文拉法辛组HAMD评分与帕罗西汀组比较有显著性差异(P<0.05),其他各时点两组间HAMD评分无显著性差异(P>0.05);两组不良反应均较轻微,组间比较无显著性差异(P>0.05)。结论文拉法辛和帕罗西汀治疗抑郁症的疗效无显著差异,不良反应均较轻,但文拉法辛起效更快,值得推广应用。

Objective To compare clinical efficacy and adverse reactions of venlafaxine and paroxetine in the treatment of depression. Methods 92 patients with depression were randomly divided into venlafaxine group and paroxetine （each group 46 patients）.The course of treatment was 8 weeks. Hamilton depression rating scale （HAMD） and side effects scale （TESS） were used to assess the efficacy and adverse reactions respectively before treatment and 1,2,4,8 weeks after treatment. Results The significant efficiency rate and response rate were 78.26% and 91.30% for venlafaxine group and were 76.08% and 89.13% for paroxetine group respectively at 8 weekend after treatment（P〉0.05）,The scores of HAMD for both groups were obviously decreased after treatment （P〈0.01）.HAMD in venlafaxine group were statistically lower than those in paroxetine group＇ at the firsth weekend （P〈0.05）.The differences became insignificant in the other time points（P〉0.05）.Adverse reactions of both groups was mild and there was no significant difference between both groups（P〉0.05）.Conclusion Venlafaxine and paroxetine in the treatment of depression has no significant difference in efficacy, and their adverse reactions are slight,but the former acts more rapidly ,so it is worthy of application.