瑞舒伐他汀对类风湿关节炎伴血脂异常患者的疗效观察

The Clinical Observation of Ruishu Laval Statin on Lipid Profile in Patients with Rheumatoid Arthritis

目的观察瑞舒伐他汀对类风湿关节炎(RA)伴血脂异常患者的疗效。方法选取2013年3月至2014年3月我院风湿科就诊的RA伴血脂异常患者80例,随机分为A、B组,每组40例。A组联合应用甲氨蝶呤、白芍总苷、硫酸羟氯喹治疗,B组在A组治疗基础上加用瑞舒伐他汀。分别于治疗前、治疗后28周记录患者胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、关节肿胀数、关节压痛数、血沉(ESR)、C-反应蛋白(CRP)、DAS28的变化,比较2组不良反应情况。结果治疗28周后,2组患者TC、TG、LDL-C均显著低于治疗前,HDL-C显著高于治疗前(P<0.05或P<0.01);2组患者DAS28、ESR、CRP、关节压痛数、关节肿胀数与治疗前比较均显著降低(均P<0.01)。B组治疗后DAS28、ESR、CRP改善显著优于A组(P<0.05或P<0.01)。2组不良反应发生率无显著差异(P>0.05)。结论 RA患者存在血脂水平异常,瑞舒伐他汀对RA有直接治疗作用。

Objective To observe the effection of Rui sbu laval statin on lipid profile in patients with rheumatoid arthritis and its safety. Methods From March 2013 to March 2014 in the hospital department of rheumatism, 80 RA patients were randomly divided into A and B two groups of 40 cases. The a group conbined with methotrexate, radix paeoniae alba total glycosides, hydroxychloroquine for the treatment of RA, B group, based on A group＇s treatment, were added on Ruishu laval statin. Some index were observed in tow group before treatment and 28 weeks after treatment, were added on Ruishu lava1 statin. Some index were observed in two group before treatment and 28 weeks after treatment, cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）, swelling index, joint pain index, time of morning stiffness, C-ractive protein（CRP）, erythrocyte sedimentation rate（ESR）, DAS28. While the patient in the tow group therapy during the occurrence of adverse reactions were statistically analyzed. Results After 28 weeks treatment, TC, TO, LDL-C, both in two groups of patients, were lower than that before treatment, and HDL-C higher than that before tteament, there were significant differences（P〈0.05 or P〈0.01）, after 28 weeks, DAS28, ESR, CRP, joint tenderness, joint swelling and morning stiffness time, both in two groups RA patients. Compared with before treatment significantly reduced, there were a very significant difference（P〈0.05 or P〈0.01 ）. But the therapeutic effects of group B were better than those of group A（P〈0.05 or P〈0.01）. The two group of patients had adverse reactions, mainly gastrointestinal discomfort and skin itching. Adverse events rates of the e two groups had no significant difference（P〉0.05）. Conelusiou RA patients have abnormal blood lipid level, Ruishu laval statin has a direct effect on the treatment of rheumatoid arthritis.