高剂量异烟肼与延长强化期对结核性脑膜炎的疗效研究

Curative Effect Research of High Dose of Isoniazid and Prolongation of Intensive Phase in Treatment of Tubercular Meningitis

目的：探究高剂量异烟肼与延长强化期对结核性脑膜炎的疗效。方法选取入我院治疗的结核性脑膜炎患者80例，按照治疗方法的不同平均分为两组，即对照组和试验组。其中对照组的患者持续治疗18个月，强化期为3个月，异烟肼剂量为0.3 mg/d；而试验组的强化期增加6个月，在此期间异烟肼的剂量为16～20 mg/d，在巩固期异烟肼剂量为0.6 mg/d。比较两组患者结核性脑膜炎的临床疗效。结果试验组的临床治疗的总有效率（92.50%）高于对照组的临床治疗的总有效率（67.50%），在统计学上有意义（P〈0.05）。结论高剂量异烟肼与延长强化期治疗结核性脑膜炎的疗效明显提高，具有可靠性。

Objective To study the curative effect of high dose of isoniazid and prolongation of intensive phase in treatment of tubercular meningitis. Methods 80 patients with tubercular meningitis in our hospital were selected and divided into control group and experimental group according to different treatments, 40 cases of each group. The patients of control group with continuous treatment of 18 months and intensive phase was 3 month with 0.3 mg/d Isoniazid. The patients of experimental group were treated with 16~20 mg/d in 6 months of intensive phase and 0.6 mg/d Isoniazid in consolidation period. The clinical efficacy for tubercular meningitis of two groups was compared. Results The total effective rate of experimental group（92.50%）was significantly higher than that of control group（67.50%）（P〈0.05）. Conclusion For patients with tubercular meningitis,the curative effect of high dose of isoniazid and a longer intensive phase is significantly improved. The reliable treatment is worth promoting in clinic.