抗癫痫药治疗脑炎后癫痫的临床探析

Clinical Study of Anti-epileptic Medication in Treatment of Postencephalitic Epilepsy

目的：对抗癫痫药治疗脑炎后癫痫的临床疗效进行探讨分析。方法选取于2014年1月～2015年1月期间在我院接受治疗的60例脑炎后癫痫患者并随机分为三组，分别是托吡酯组、丙戊酸钠组、卡马西平组，三组患者给予相应药物治疗并对临床效果进行比较。结果托吡酯组、丙戊酸钠组、卡马西平组三组的治疗总有效率分别为95%、75%和70%，不良反应发生率分别为10%、30%和35%，差异有统计学意义（P〈0.05）。结论抗癫痫药治疗脑炎后癫痫具有显著的临床疗效，尤其是托吡酯，丙戊酸钠和卡马西平其次。

Objectives To explore the clinical effect of anti-epileptic medication in treatment of postencephalitic epilepsy. Methods 60 patients of postencephalitic epilepsy were chose who were treated in our hospital from January 2014 to January 2015 and randomly divided them into Topiramate group,Valproate group and carbamazepine group. Three groups of patients were given corresponding drug treatment and then compared the treatment effects of these three groups. Results The total effective rate was 95% of Topiramate group,and that was 75% of Valproate group and that was 70% of carbamazepine group. The adverse effects rate of these three groups was 10%,30% and 35% respectively. There was significant difference among three groups（P〈0.05）. Conclusion The effect of anti-epileptic medication in treatment of postencephalitic epilepsy is quite effective. Especially the treatment effect of topiramate is more significant,Valproate and carbamazepine are the second.