美沙拉嗪治疗溃疡性结肠炎的临床分析

Clinical Analysis of Mesalazine Medication in Treatment of Ulcerative Colitis

目的：分析美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法搜集本院肛肠科2014年1月～2015年1月收治的46例溃疡性结肠炎患者，根据使用药物的不同分为两组，甲组给予美沙拉嗪药物治疗，乙组给予柳氮磺砒啶药物治疗，对比两组治疗效果。结果两组比较，甲组患者治疗总有效率为96.0%（24/25），高于乙组的85.7%（18/21），且甲组不良反应的发生率8.0%，低于乙组的23.8%，差异有统计学意义（P〈0.05）；治疗后两组组织学积分均有所下降，且甲组组织学积分下降情况大于乙组，差异有统计学意义（P〈0.05）。结论美沙拉嗪治疗溃疡性结肠炎的临床疗效显著，可提高患者的治愈率，降低不良反应的发生率。

Objective To analysis the clinical effect of mesalazine medication in treatment of ulcerative colitis. Methods 46 patients with ulcerative colitis were chose who were treated in anorectal department in our hospital from January 2014 to January 2015. The patients were divided into group A and group B according to different treatment methods. The group A was given mesalazine medication treatment and the group B was given sulfasalazine medication treatment. And then made a comparative study on treatment effects between two groups. Results The total effective rate of group A was 96.0%（24/25） which was much higher than that was 85.7%（18/21）of Group B. There was a great differential between two groups（P〈0.05）. The incidence of adverse effect of Group A was 8.0%which was much lower than that was 23.8%in Group B. There was significant difference between two groups. The histopathologic scores had been declined after treatment in two groups. The decreased degree of group A was much better than that of Group B. There was a great differential between two groups（P〈0.05）. Conclusion The clinical efficacy of mesalazine medication in treatment of ulcerative colitis is significantly. It is conducive to increasing cure rate and reducing the rate of adverse.