甲氨蝶呤联合米非司酮治疗宫外孕的效果观察

Effect Observation of Mifepristone Combined With Methotrexate in the Treatment of Ectopic Pregnancy

目的：对甲氨蝶呤联合米非司酮治疗宫外孕的临床效果进行观察研究。方法选取于2014年2月～2015年3月在我院接受治疗的48例宫外孕患者，将患者随机分为对照组和治疗组进行对照研究，观察甲氨蝶呤和甲氨蝶呤联合米非司酮的临床治疗效果。结果治疗组患者的治愈率高于对照组，包块直径、血β-HCG、血孕酮以及不良反应发生率均低于对照组，差异有统计学意义（P〈0.05）。结论米非司酮联合甲氨蝶呤治疗宫外孕有显著疗效，能够保持患者的生育能力并且安全有效。

Objective To observe on the clinical effect of mifepristone combined with methotrexate in treatment of ectopic pregnancy. Methods 48 patients of ectopic pregnancy who were treated in hospital from February 2014 to March 2015 were chosen and the patients were randomly divided into treatment group and control group. Clinical observation of the therapeutic effect of methotrexate and mifepristone combined with methotrexate. And then compared treatment effects between two groups. Results The cure rate of the treatment group were significantly higher than that of control group. The mass diameter,β-HCG,progesterone and the incidence of adverse reactions of treatment group were significantly lower than of the control group. The difference was significant,the result is statistical y significant（P〈0.05）. Conclusion Mifepristone combined with methotrexate in treatment of ectopic pregnancy has a significant effect. This method can keep patients with fertility and it is safe and effective.