阿替普酶静脉溶栓治疗急性心肌梗死疗效观察

Curative Effect Observation of Intravenous Thrombolysis With Alteplase in Treatment of Acute Myocardial Infarction

目的探讨使用阿替普酶静脉溶栓治疗急性心肌梗死的临床效果。方法将88例急性心肌梗死患者作为观察对象,随机分为观察组与对照组各44例。对照组使用50 mg阿替普酶实施静脉溶栓治疗;观察组使用100 mg阿替普酶进行治疗。对两组患者的治疗后冠状动脉再通率以及死亡率进行比较。结果对照组患者中静脉再通有28例,再通率为63.64%,死亡3例;观察组患者冠状动脉再通有为36例,再通率为81.82%,死亡1例。两组的冠状动脉再通率的差异具有统计学意义(P<0.05);死亡之间差异不具有统计学意义(P>0.05)。结论使用阿替普酶静脉溶栓的方式治疗急性心肌梗死的效果显著,能够发挥局部溶栓的作用,再通冠状动脉,安全系数高。

Objective To investigate the clinical results of using intravenous thrombolytic with alteplase in the treatment of acute myocardial infarction. Methods 88 patients with acute myocardial infarction were chose as observation object. The patients were randomly divided into observation group and control group, 44 cases in each group. The patients of control group were treated with 50 mg intravenous thrombolytic with alteplase while that of observation group were treated with 100 mg intravenous thrombolytic with alteplase. Recanalization rate of coronary artery and mortality of the two groups were compared after treatment. Results 28 cases in the control group showed the recanalization,the rate was 63.64%,3 cases died. 36 cases of observation group showed the recanalization,the rate was 81.82%,1 case died. The differences of the rate of coronary recanalization was statistical y significant in two groups（P〈0.05）. The difference was not statistical y significant of mortality（P〉0.05）. Conclusion The effect of thrombolytic therapy with alteplase in the treatment of acute myocardial infarction is significant. It can be able to play the role of local thrombolysis and recanalization of coronary artery.