乳腺癌患者CT征象与SIRT1表达水平的关系研究

Correlation of SIRT1 Expression With CT Appearance in Breast Cancer Patients

目的研究SIRT1表达水平与乳腺癌患者CT征象的关系。方法研究纳入经病理诊断确诊的乳腺癌患者45例,收集患者乳腺癌组织和对应癌周正常组织标本,免疫组织化学法分析SIRT1的表达变化。利用CT行乳腺常规扫描,观察病灶形态、边缘、生长方式、钙化及坏死等直接征象和腋窝淋巴结转移等间接征象。分析SIRT1与乳腺癌患者CT表现的关系。结果乳腺癌组织中的SIRT1阳性表达率较高,乳腺癌患者的部分CT影像学特征与其SIRT1表达相关:SIRT1表达情况与乳腺癌病灶CT下的形态无关,SIRT1表达情况与病灶边缘形态有关,对于高SIRT1表达的患者,边缘毛刺征较为常见;从病灶生长分布形态来看,高SIRT1表的患者,其肿块和浸润弥漫分布的例数较多,肿块型的病灶直径较大。间接征象方面,钙化程度与SIRT1表达无关,SIRT1高表达的患者出现内部坏死的例数较多,更重要的是,高SIRT1表达的患者其腋窝淋巴结转移的例数较多。结论 SIRT1可能参与乳腺癌的发生和发展,SIRT1检测与患者的CT像学征象有关,二者联合可提高乳腺癌的诊断价值。

To analyse the corrclation of SIRT1expression with CT appearance in breast cancer patients.Methods This stduy selected 45 patients with parhologically diagnosed breast cancer.Tumor tissue samples and matched adjacent normal tissue samples were collected and the SIRT1 expressions in tissue samples were analyzed by immunohistochemistry.CT appearance of all cases including lesions characters,calcification degree and nectosis degree were detected,also the lymph node metastasis status of partients were detemined.Assay was performed to shown the relationship between expression changes of ISRT1 and CT appearance.Results Compared with normal tissue,in cancer tissue,SIRT1 expression was higher dramatically,meanwhile ,some of the CT appearance in patients were related to the level of SIRT1.In brief,There was no association between lesion shape and SIRT 1 expression,however,the margin character of lesion was related to the SIRT1.It was more common that higher SIRT1 patients shown spiculation.Considering the growth charcters of lesions,we found that the lesions in most of higher SIRT1patients were massive type or diffuse type with a langer diameter.No evidence showed that SIRT1 expression was associated with calcification,but higher SIRT1 patients tended to show necrosis in lesions.More importandy ,more lymph node metastasis was observed in higher SIRT1 patients.Conclusion There is definite correlation between SIRT1 expression and the CT appearance in breast cancer patients.SIRT1 could be used in combination with CT to diagnose breast cancer.