IL-1B基因多态性与宫颈高危HPV持续感染遗传易感性的相关性

Relationship between gene polymorphism of IL-1B and susceptibility of high-risk HPV persistent infection in cervix uteri

目的探讨IL-1BT-31C和C-511T基因多态性与宫颈高危人乳头瘤病毒(HPV)持续感染遗传易感性的关系。方法采用聚合酶链式反应和限制性片段长度多态性(PCR-RFLP)检测中国江苏部分地区高危HPV持续感染(A组,223例)和感染自我清除的汉族女性(B组,186例)IL-1B T-31C、C-511T基因型分布。结果两组IL-1BT-31C和C-511T位点各基因型分布无统计学差异(P>0.05)。IL-1BT-31C和C-511T位点的基因频率与HPV持续感染遗传易感性均无明显相关性(P>0.05)。结论在中国江苏汉族女性人群中,IL-1B T-31C和C-511T基因多态性可能与高危HPV持续感染遗传易感性无关。

Objective To investigate the relationship between gene polymorphism of IL-1B and susceptibility of high-risk human papilloma virus（HPV） persistent infection in cervix uteri. Methods The genotype distribution of IL-1B T-31C and C-511T of Chinese women in Jiangsu province was detected by PCR-RFLP in 223 cases of HPV persistent infection（group A） and 186 cases of non-HPV persistent infection（group B）. Results The genotype distribution of IL-1B T-31C and C-511T in group A was similar to that in group B（P〉0. 05）. There was no significant correlation between gene frequency of IL-1B and susceptibility of high-risk HPV persistent infection （P〉0. 05）. Conclusion The gene polymorphism of IL-1B T-31C and C-511T may not be responsible for the susceptibility of high-risk HPV persistent infection in Chinese women in Jiangsu province.