细胞内β淀粉样蛋白降解机制研究进展

Progress on the Mechanism of Intracellular Degradation of β-Amyloid Protein

阿尔茨海默病(Alzheimer’s disease,AD)是老年人中最常见的神经退行性疾病。β淀粉样蛋白(β-amyloid protein,Aβ)被认为是影响AD进程最主要的致病因子。脑内Aβ的产生和降解之间存在平衡,Aβ产生增多、降解减少在AD的发病过程中起着重要作用。细胞内Aβ降解主要在溶酶体中进行,最近研究发现,溶酶体调节剂能改善Aβ引起的学习记忆损伤,提示可以通过调节溶酶体功能治疗AD。这些发现使溶酶体介导的细胞内Aβ降解机制重新受到重视,该文重点综述溶酶体介导的细胞内Aβ降解机制以及与之相关的Aβ摄取和转运机制。

Alzheimer＇s disease （AD） is one of the most common neurodegenerative diseases in elderly peo- ple. β-amyloid protein （Aβ） is considered to be the most important pathogenic factor affecting the process of AD. There is a balance between production and degradation of Aβ in brain. Besides the increased production of Aβ, the decreased degradation also plays an important role in the process ofAD. Lysosome is the main organelle for intra- cellular Aβ degradation. Recent studies found that lysosome modulators could prevent the impairment of learning and memory induced by Aβ These findings suggest a serious role of lysosome in the intracellular degradation of Aβ Our goal is to understand the mechanism of Aβ degradation mediated by lysosome, and the related mechanisms of Aβ uptake and transportation.