雌激素受体及芳香化酶在牙龈癌组织中的表达和意义

Estrogen receptor and aromatase expression in gingival carcinoma tissue

目的:观察牙龈癌中雌激素受体(ER)与芳香化酶的表达情况,探讨局部雌激素及芳香化酶在牙龈癌中的作用与关系。方法:免疫组化过氧化物酶标记的链酶卵白素法测定雌激素受体及芳香化酶在牙龈癌中的表达。结果:牙龈癌组雌激素受体及芳香化酶的表达阳性率分别为50%和42.86%,正常对照组分别为13.33%和6.67%(P<0.05);牙龈癌中雌激素受体与芳香化酶之间未见明显相关性。结论:牙龈癌有一定的雌激素依赖性;芳香化酶在牙龈癌组织中表达升高,但芳香化酶并不是影响局部雌激素受体升高的唯一因素。

AIM： To investigate the expression of estrogen receptor（ ER） and aromatase in gingival carcinoma. METHODS： ER and aromatase were detected by immunohistochemical staining SP method in gingival carcinoma（ n = 28） and normal gingival tissues（ n = 15）. RESULTS： Positive expression rates of ER and aromatase expression in gingival carcinoma were 50. 00% and 42. 86%,in normal gingival tissues were 13. 33% and 6. 67%,respectively（ P〈0. 05）. No significant correlation was found between ER and aromatase in gingival carcinoma. CONCLUSION：Estrogen metablism might be related to gingival carcinoma. Aromatase is not the exclusive reason of the high positive rate of ER.