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胶质瘤CpG岛甲基化表型的研究进展 被引量:2

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摘要 胶质瘤CpG岛甲基化表型(glioma-CpG island methylatorphenotype, G-CIMP)是新近提出的概念,它从全基因组的视角描述胶质瘤中启动子CpG岛异常高甲基化的特征。G-CIMP可见于大多数WHO分级Ⅱ、Ⅲ级的胶质瘤和继发性胶质母细胞瘤,对于胶质瘤的预后和分子分类具有潜在的临床应用价值,现就G—CIMP的研究进展做一综述。一。
出处 《中华神经外科杂志》 CSCD 北大核心 2015年第5期530-532,共3页 Chinese Journal of Neurosurgery
基金 国家自然科学基金(81460382)
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  • 1Esteller M. Epigenetics in cancer[J] . N EnglJ Med, 2008,358 (11) :1148-1159.
  • 2Bonasio R, Tu S, Reinberg D. Molecular signals of epigenetic states[J]. Science ,2010 ,330( 6004) :612-616.
  • 3Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future[J] . Patholog Res Int, 2011,2011:902674.
  • 4Laird PW. The power and the promise of DNA methylation markers[n. Nat Rev Cancer ,2003,3 (4) :253-266.
  • 5van Engeland M, Derks S, Smits KM, et al. Colorectal cancer epigenetics , complex simplicity[J] .J Clin Oneol ,2011,29 (10) : 1382-1391.
  • 6Toyota M, Ahuja N, Ohe-Toyota M, et al. CpG island methylator phenotype in colorectal cancer]J J. Proc Natl Acad Sci USA. 1999,96(15) :8681-8686.
  • 7Hughes LA, Khalid-de Bakker CA, Smits KM, et al. The CpG island methylator phenotype in colorectal cancer: progress and problems[J]. Biochim Biophys Acta,2012,1825(1) :77-85.
  • 8Juo YY,Johnston FM, Zhang DY, et al. Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis. t n. Ann Oncol, 2014,25 (12) :2314-2327.
  • 9Fang F, Turcan S, Rimner A, et al. Breast cancer methylomes establish an epigenomic foundation for metastasis[J]. Sci Transl Med,2011 ,3(75) :75ra25.
  • 10Hughes LA, Melotte V, de SchrijverJ, et al. The CpG island methylator phenotype: what' s in a name?[J]. Cancer Res, 2013 ,73( 19) :5858-5868.

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