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垂体细胞瘤5例并文献复习 被引量:3

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摘要 目的:探讨垂体细胞瘤的临床病理学特征及诊断要点。方法复习5例垂体细胞瘤的临床资料、影像学、组织学及免疫组化结果,并结合文献探讨其诊断及鉴别诊断。结果5例垂体细胞瘤中女性3例,男性2例,年龄22-49岁,3例为体检时或偶然发现,头颅CT和MIR示鞍区占位。镜下见瘤细胞长梭形、短梭形,胞核卵圆形,束状、交织状排列,部分细胞多形性,核分裂象罕见。免疫表型:肿瘤均表达vi-mentin、S-100、TTF-1,Ki-67增殖指数<2%,部分表达EMA、GFAP,不表达垂体激素。结论垂体细胞瘤是起源于鞍区和鞍上区神经垂体细胞的罕见肿瘤,生长较缓慢,属于WHOⅠ级,实际工作中需与毛细胞型星形细胞瘤、梭形嗜酸细胞瘤和脑膜瘤等进行鉴别。
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第5期589-591,共3页 Chinese Journal of Clinical and Experimental Pathology
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参考文献13

  • 1Louis D N, Ohgaki H,Wiestler O D, et al. World Health Organization classification of tumours of the central nervous system[M]. Lyon: IARC Press, 2007:243-4.
  • 2Yilmaz O, Turan A, Yigit H, et al. Case of pituicytoma in childhood[J]. Childs Nerv Syst, 2012,28(1):11-2.
  • 3Nakasu Y, Nakasu S, Saito A, et al. Pituicytoma. Two case reports[J]. Neurol Med Chir, 2006,46(3):152-6.
  • 4Wolfe S Q, Bruce J, Morcos J J. Pituicytoma: case report[J]. Neurosurgery, 2008,63(1):E173-4.
  • 5Secci F, Merciadri P, Rossi D C, et al. Pituicytomas: radiological findings, clinical behavior and surgical management[J]. Acta Neurochir, 2012,154(4):649-57.
  • 6Gibbs W N, Monuki E S, Linskey M E, et al. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging[J]. AJNR Am J Neuroradiol, 2006,27(8):1639-42.
  • 7Mele O, Lopes M B, Asa S L. Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma[J]. Am J Surg Pathol, 2013,37(11):1694-9.
  • 8Katsuta T, Inoue T, Nakagaki H, et al. Distinctions between pituicytoma and ordinary pilocytic astrocytoma[J]. J Neurosurg, 2003,98(2):404-6.
  • 9Kowalski R J, Prayson R A, Mayberg M R. Pituicytoma[J]. Ann Diagn Pathol, 2004,8(5):290-4.
  • 10Zhang F, Chen J, You C. Pituicytoma: case report and review of the literature[J]. Neurol India, 2010,58(5):799-801.

二级参考文献11

  • 1Shi Y,Morgenstern N.Granular cell astrocytoma[J].Arch Pathol Lab Med,2008,132(12):1946-50.
  • 2Brat D J,Scheithauer B W,Medina-Flores R,et al.Infiltrative astrocytomas with granular cell features (granular cell astrocytomas):a study of histopathologic features,grading,and outcome[J].Am J Surg Pathol,2002,26:750-7.
  • 3Geddes J F,Thom M,Robinson S,et al.Granular cell change in astrocytic tumors[J].Am J Surg Pathol,1996,20:55-63.
  • 4Melaragno M J,Prayson R A,Murphy M A,et al.Anaplastic astrocytoma with granular cell differentiation:case report and review of the literature[J].Hum Pathol,1993,24:805-8.
  • 5Saad A,Mo J,Miles L,et al.Granular cell astrocytoma of the cerebellum:report of the first case[J].Am J Clin Pathol,2006,126:602-7.
  • 6Castellano-Sanchez A A,Ohgaki H,Yokoo H,et al.Granular cell astrocytomas show a high frequency of allelic loss but are not a genetically defined subset[J].Brain Pathol,2003,13(2):185-94.
  • 7Rickert C H,Kuchelmeister K,Gullotta F.Morphological and immunohistochemical characterization of granular cells in non-hypophyseal tumours of the central nervous system[J].Histopathology,1997,30:464-71.
  • 8Claassen U,Kuntz G,Schmitt H P.Malignant intracerebral granular cell tumor reacts positively with anti-alpha-1-antichymotrypsin and the MB2 antibody:a clue to the histogenesis of the brain granular cell[J].Clin Neuropathol,1990,9:82-8.
  • 9Chorny J A,Evans L C,Kleinschmidt-Demasters B K.Cerebral granular cell astrocytomas:a Mib-1,bcl-2 and telomerase study[J].Clin Neuropathol,2000,19:170-9.
  • 10Shin E,Ki Chung C,Park S H.Granular cell astrocytoma[J].Pathol Res Pract,2007,203(1):57-62.

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