277例晕痣的临床回顾性分析

A retrospective clinical analysis of 277 cases of halo nevus

目的:总结晕痣的临床特点,初步探讨晕痣与白癜风的临床相关性。方法:对277例晕痣患者的临床特点进行分析,并对部分患者进行随访。结果:277例行晕痣切除术的患者中,皮损单发219例(79.06%),多发58例(20.94%)。好发于面颈部(54.86%)与躯干(37.03%)。106例患者(38.27%)并发白癜风,其平均发病年龄小于未并发白癜风者(P=0.041)。随访110例未并发白癜风的晕痣患者术后转归,17例继发白癜风,其中11例于半年内发生。比较未并发白癜风的晕痣患者与继发白癜风的晕痣患者,后者多发晕痣的比例高于前者(P=0.003)。结论:晕痣皮损以单发多见,面颈部好发。晕痣发病年龄小、皮损多发是白癜风发病的危险因素。手术切除是治疗晕痣的一种有效方法,晕痣切除术后半年可能是白癜风发生的高风险期,应密切随访。

Objective： To reveal the clinical characteristics of halo nevus and explore the relationship between halo nevus and vitiligo. Methods＇ The clinical features of 277 cases of halo nevus were analyzed, and some patients were followed up. Results： Two hundred and seventy-seven cases of halo nevus patients were treated with excision, among them 219 cases were of solitary lesions（79.06%）, and 58 cases were of multiple lesions（20.94%）. The halo nevus showed a predilection for the face and neck（54.86%）, and trunk（37.03%）. One hundred and six cases of halo nevus（38.27%） complicated with vitili- go, whose average age of onset was less than the patients without vitiligo（P=0.041）. Postoperative outcome of 110 cases with- out vitiligo were followed up, 17 cases occurred vitiligo secondary, of which 11 cases occurred within half a year. Compared with the patients with vitiligo, the ratio of muhiple lesions of halo nevus was higher in the patients without secondary vitiligo （P=0.003）. Conclusion： Solitary lesion of halo nevus is the most common and always occurs on the face and neck. The lower onset age and multiple lesions of halo nevus are the risk factors in the pathogenesis of vitiligo. Surgical resection is an effective method for the treatment of halo nevus, half a year after excision may be the high risk period of development of vitiligo, which should be closely followed up.