椎间盘中结缔组织生长因子:对细胞基质数量的合成代谢作用

Connective tissue growth factor in the intervertebral discs exerts an anabolic effect on the extracellular matrix

背景:目前对于结缔组织生长因子同骨科相关疾病的研究并不多,自然对间盘范围内的研究就少之又少。目的:通过研究结缔组织生长因子在退变间盘及其相关组织中的作用和机制,为间盘退行性变的生物治疗提供新的更有价值的借鉴。方法:由第一作者应用计算机检索Pub Med、中国期刊全文数据库(CNKI)1997年1月至2014年10月相关文献。在标题、摘要、关键词中以"intervertebral disc;CTGF;TGF-β;hypoxia;disc degeneration"或"椎间盘;结缔组织生长因子;转化生长因子β;低氧;间盘退变"为检索词进行检索。选择文章内容与结缔组织生长因子在退变间盘及其相关组织中的作用和机制有关者,同一领域文献则选择近期发表在权威杂志文章,最终选择34篇文献进行综述。结果与结论:有关间盘的研究,许多体内和体外实验已经表明结缔组织生长因子具有刺激髓核细胞基质产量的合成代谢作用,其凭借对类似转化生长因子β和缺氧的调节及刺激,表明了转化生长因子β和结缔组织生长因子这一作用轴对细胞基质数量的重要性;而缺氧是对结缔组织生长因子作用的另一种调节,其主要凭借对细胞类型的控制以及依赖方式的表达来发挥作用。

BACKGROUND： Because of the deficiency of researches on connective tissue growth factor associated with orthopedic diseases, very little attention has been paid to the studies on connective tissue growth factor in the intervertebral disc. OBJECTIVE： Through exploring the role and mechanism of connective tissue growth factor in disc degeneration, to provide new evidence for biotherapy of disc degeneration. METHODS： A computer-based search of Pub Med and CNKI was performed by the first author to retrieve articles relevant to the effect and mechanism of connective tissue growth factor on degenerative disc and its related tissues published from January 1997 to October 2014. The keywords were ＂intervertebral disc; CTGF; TGF-β; hypoxia; disc degeneration＂ in Chinese and English, respectively, which appeared in the title, abstract or keywords. Articles published recently or in authoritative journals were preferred, and finally 34 articles were included in result analysis. RESULTS AND CONCLUSION： Recently in vivo and in vitro studies on the intervertebral disc have clearly demonstrated the anabolic role of connective tissue growth factor in stimulating matrix production from nucleuspulposus cells and revealed that the transforming growth factor β-connective tissue growth factor axis was of great importance to cellular matrix production via regulations and stimulations to transforming growth factor β and hypoxia, while the regulation of hypoxia for connective tissue growth factor was another in a specific cell and tissue manner.