急性运动成年人血浆胃肠激素肽水平变化的Meta分析

Acute exercise leads to varying peptide YY levels in adults: a Meta-analysis

背景:有研究认为急性运动可能是通过影响胃肠激素肽的合成和分泌来调节食欲影响摄食行为,但是目前此方面的相关研究样本量较小且结果迥异。目的:运用Meta分析法评估急性运动对成年人胃肠激素肽(酪酪肽)水平的影响。方法:检索Pub Med、Google Scholar、Sport Discus、Web of Knowledge及CNKI数据库检索截止时间到2014年1月。采用Rev Man5.1软件进行Meta分析,发表性偏倚和异质性检验,数据合并和敏感性分析。结果与结论:1共有11篇符合纳入标准的文献,对18项随机对照试验188名受试者进行Meta分析急性运动对健康人血浆酪酪肽水平影响,结果发现资料有同质性合并效应量标准化均数差(SMD)合并=0.25,95%CI=0.05-0.46,P=0.01,故认为急性运动组与对照组相比酪酪肽水平在统计学上有显著性差异(P<0.05),且敏感性分析并未改变Meta分析的结果。2纳入3篇急性运动对健康成人血浆酪酪肽(3-36)的影响文献,5项随机对照实验,32名受试者进行Meta分析:异质性显著,故采用随机效应模型进行分析。合并标准化均值差标准化均数差(SMD)合并=1.80,95%CI=0.27-3.32,P=0.02,故急性运动上调了酪酪肽(3-36)水平。结果提示,急性运动可以增加成年人血浆胃肠激素肽水平,其水平变化可能会与运动后摄食量变化有关。

BACKGROUND： Acute exercise is believed to regulate appetite and influence feeding behaviors by controlling the synthesis and secretion of gastrointestinal peptide hormones to regulate appetite and feeding behavior influence, but the small sample size leads to widely different results. OBJECTIVE： To clarify the effect of acute exercise on peptide YY levels in adults using Meta-analysis method. METHODS： A computer-based search of PubMed, Google Scholar, Sport Discus, Web of Knowledge and CNKI was performed for relevant articles published before January 2014. The literatures eligible were studied by evaluating the publication bias, checking the heterogeneity and analyzing the sensitivity by software of RevMan5.1. RESULTS AND CONCLUSION： （1） There were a total of 188 participants in the 18 trials reported in 11 articles. The Meta-analysis results revealed a mean effect for acute exercise to increase peptide YY values （standardized mean difference=0,25, 95% confidence interval =0.05-0.46, P=0.01 ）, and therefore, there was a significantly statistical difference in the peptide YY levels between the acute exercise group and control group （P 〈 0.05）. Moreover, results from the sensitivity analysis showed no influences on the findings of Meta-analysis. （2） Five randomized controlled trails in the three included articles were related to peptide YY （3-36）. There was a maximal heterogeneity among these studies; therefore, a random-effect model was utilized. The result revealed a mean effect for acute exercise to increase peptide YY （3-36） values （standardized mean difference =1.80, 95% confidence interval =0.27-3.32, P=0.02）. The findings from this meta-analysis show that acute exercise may influence appetite by increasing levels of peptide YY in adults.