双歧杆菌四联活菌片治疗肝硬化腹泻患者的疗效及其机理探讨

Clinical curative effect of bifidobacterium tetravaccine tablets in the treatment of cirrhotic patients with diarrhea and influence on sIgA levels and cellular immune function

目的探讨双歧杆菌四联活菌片治疗肝硬化腹泻患者的临床疗效以及对肠道s Ig A水平和细胞免疫功能的影响。方法选取120例肝硬化腹泻的患者,将其随机分为两组。对照组给予抗病毒、护肝利尿、消炎、解痉和营养支持等常规肝硬化腹泻治疗,观察组则在对照组的基础上减消炎、解痉药加用双歧杆菌四联活菌片治疗。疗程均为4周。观察并比较两组患者的临床治疗效果、肠道s Ig A水平变化以及细胞免疫功能的改善情况。结果观察组总有效率为96.67%,显著高于对照组的78.33%(P<0.05);治疗后两组患者ALT、AST、TBIL水平均较治疗前明显下降,SIg A水平较治疗前明显上升(P<0.05),且观察组下降或上升幅度均大于对照组,两组比较差异具有统计学意义(P<0.05);观察组治疗后CD4+和CD4+/CD8+比值较治疗前明显升高,且高于对照组,差异有统计学意义(P<0.05);CD8+水平与治疗前比较差异无统计学意义(P>0.05)。结论双歧杆菌四联活菌片治疗肝硬化腹泻疗效显著,可以有效地提高患者肠道s Ig A水平,增强患者细胞免疫功能。

Objective To explore the clinical efficacy of bifidobacterium tetravaccine tablets in the treatment of cirrhotic patients with diarrhea and its influence on sIgA levels and cellular immune function. Methods One hundred and twenty cirrhotic patients with diarrhea in our hospital were randomly divided into two groups. The patients in control group was treated with antiviral medication, diuresis, nutritional support as well as other conventional treatments, and patients in observation group was treated with bifidobacterium tetravaccine tablets on the basis of the control group. The treatment effect and the changes of intestinal sIgA levels and cellular immune function of the two groups were observed and compared. Results After treatment, the total effective rate of observation group was 96.67%, significantly higher than 78.33% in the control group （P 〈 0.05）. The levels of ALT, AST, TBIL were significantly decreased than before the treatment, and the level of slgA was significantly increased when compared with those before the treatment （P 〈 0.05）. There was also a signif- icant difference concerning the levels of ALT, AST, TBIL, and slgA between two groups after the treatment. Levels of CD4~ and CD4~/CD8~ in the observation group were significantly higher than that in control group （P 〈 0.05）. Conclusion Bifidobacterium tetravaccine tablets in the treatment of cirrhotic patients with diarrhea had significant clinical efficacy, could improve the intestinal slgA level and enhance the cellular immune function of the patients effectively.