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内质网应激通过多种信号通路调节系统性红斑狼疮发病的研究进展 被引量：1

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摘要 系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病。内质网是细胞发挥各种功能的重要场所,是整合多种应激反应的交汇点。内质网膜上存在完整的信号调节机制-内质网应激(ERS)反应机制,细胞凋亡、炎症、免疫异常参与SLE的发病过程,并且ERS可作为共同通路将凋亡、炎症、免疫等多条信号通路联系起来,再通过其下游信号对细胞凋亡、炎症、免疫反应等生理病理活动进行调控。为更好地理解SLE的发病机制,本文对ERS、细胞凋亡、炎症、免疫反应与SLE之间关系的研究进展进行了综述。
作者 杨明 桂明 王丽 杜庆
机构地区 中南大学湘雅三医院肾内风湿免疫科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2015年第7期989-991,995,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 湖南省自然科学基金(14JJ2037)
关键词 系统性红斑狼疮 内质网应激 凋亡 炎症 免疫 综述
分类号 R392.11 [医药卫生—免疫学] R593.241 [医药卫生—内科学]
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参考文献34

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二级参考文献44

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细胞与分子免疫学杂志
2015年 第7期

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