骨髓间充质干细胞体外增殖的策略

The strategies of bone marrow mesenchymal stem cells proliferation in vitro

干细胞移植治疗疾病已成为再生医学研究的热点问题,骨髓间充质干细胞具有强大的增殖能力和多向分化潜能。在一定条件诱导下,可向心肌细胞、成骨细胞、神经元细胞等方向定向分化。而如何获取足够量的骨髓间充质干细胞,为干细胞移植治疗疾病的基础研究及临床应用提供足够的干细胞来源,是个较为棘手的难题。目前,促进骨髓间充质干细胞的体外增殖方法很多,但各有利弊,文中就骨髓间充质干细胞的体外增殖方法内容及其优缺点进行综述。

The approach of stem cell transplantation to treat different types of diseases has been becoming a hot issue in the field of regenerative medicine.Potentially, bone marrow mesenchymal stem cells （BMMSCs） possess strong proliferation and multi-di-rection differentiation ability .Under special certain kind of induction circumstances , BMMSCs can trans-differentiate into myocardial cells, osteoblasts, fat cells, neurons, endothelial cells.It is difficult that how to obtain enough BMMSCs for basic and clinical studies using BMMSCs treating diseases .Currently , there are many methods of in vitro proliferation of BMMSCs with advantages and disadvan -tages.In this paper, an overview of BMMSCs proliferation strategy in vitro is provided .