建立脑死亡动物模型对中国公民逝世后器官捐献肝移植的重要性

Establishing a donation after brain death animal model is important for China donation after citizens＆#39; death of liver transplantation

目前中国已全面进入公民逝世后器官捐献（CDCD）供肝的历史新阶段.其中应用最为广泛的当属脑-心双死亡标准器官捐献（DBCD）.由脑死亡过渡到心脏死亡过程中,各种病理生理变化对供体全身脏器的影响都是不容忽视的.因此,脑死亡对供体影响的研究对于CDCD肝移植有着非常重要的意义.本文从中国公民逝世后器官捐献的启动及其分类、建立脑死亡器官捐献（DBD）动物模型的必要性及其应用等方面阐述DBD动物模型与CDCD肝移植的关系,以期起到抛砖引玉的作用.

China donation after citizens＆#39; death （CDCD） has already entered a new historical era,and the donation after brain death plus cardiac death （DBCD）,which refers to the transition from brain death to cardiac death,is most widely used.The various pathological and physiological changes have an influence on donor organs,which could not be ignored.So the research on the effects of donor brain death for CDCD liver transplantation will be of great significance.Here we discussed the CDCD initiation and its classification,and the necessity and application of establishing a donation after brain death （DBD） animal model to clarify the relationship between DBD and CDCD liver transplantation and thus to enlighten future studies.