肌筋膜疼痛综合征与血尿酸水平的关系研究

Clinical study on the relationship between myofascial pain syndromes and blood uric acid level

目的：探讨肌筋膜疼痛综合征（myofascial pain syndromes,MPS）与血尿酸水平的关系。方法：选取219例MPS患者,按照年龄分为18-29岁组、30-39岁组、40-49岁组和≥50岁组。测定患者的血尿酸水平、主要疼痛部位疼痛视觉模拟评分（visual analogue score,VAS）及压痛评分。分析患者血尿酸水平与其年龄、主要疼痛部位疼痛及压痛程度的关系。结果：18-29岁组40例、30-39岁组84例、40-49岁组57例,均为男性;≥50岁组38例,男25例、女13例。4组男性患者主要疼痛部位压痛评分、疼痛VAS评分及血尿酸水平比较,组间差异均无统计学意义[（1.30±0.46）分,（1.42±0.54）分,（1.39±0.56）分,（1.76±0.66）分,χ^2=9.712,P=0.121;（4.52±1.41）分,（4.48±1.81）分,（4.23±1.71）分,（5.20±1.71）分,χ^2=5.940,P=0.115;（500.35±138.85）μmol·L^-1,（447.81±130.97）μmol·L^-1,（467.86±123.70）μmol·L^-1,（455.32±101.99）μmol·L^-1,χ^2=4.152,P=0.246]。219例MPS患者中,138例诊断为高尿酸血症（Hyperuricemia,HUA）,男126例、女12例;18-29岁组30例、30-39岁组50例、40-49岁组37例、≥50岁组21例（男9例、女12例）。男性各年龄组HUA发生率由高至低依次为18-29岁组、40-49岁组、30-39岁组、≥50岁组。Pearson相关分析结果显示,血尿酸水平与年龄、MPS主要疼痛部位的压痛评分和疼痛VAS评分均呈正相关（r=0.425,P=0.016;r=0.496,P=0.004;r=0.402,P=0.028）。结论：MPS患者中HUA的发生率较高,且MPS患者的血尿酸水平与其年龄、疼痛及压痛程度呈正相关。

Objective：To explore the relationship between myofascial pain syndromes（MPS）and blood uric acid（BUA）level.Meth-ods：Two hundred and nineteen patients with MPS were selected and divided into group A（aged 18 -29 years）,group B（aged 30 -39 years）,group C（aged 40 -49 years）and group D（≥50 years old）.The BUA level,visual analogue score（VAS）and tenderness score of main pain sites were measured.Meanwhile the relationship between BUA level and age,pain degree and tenderness degree of main pain sites were analyzed.Results：The patients in group A（40 cases）,B（84 cases）and C（57 cases）were males,while the patients in group D （38 cases）included 25 males and 13 females.There was no statistical difference in tenderness scores and VAS of main pain sites and BUA level between the 4 groups in males（1.30 ＋/-0.46,1.42 ＋/-0.54,1.39 ＋/-0.56,1.76 ＋/-0.66 points,χ^2 =9.712,P =0.121;4.52 ＋/-1.41,4.48 ＋/-1.81,4.23 ＋/-1.71,5.20 ＋/-1.71 points,χ^2 =5.940,P =0.115;500.35 ＋/-138.85.447.81 ＋/-130.97. 467.86 ＋/-123.70,455.32 ＋/-101.99 μmol/L,χ^2 =4.152,P =0.246）.A total of 138 hyperuricemia（HUA）out of 219 MPS were diag-nosed,including 126 males and 12 females,and 30 aged 18 -29 years,50 aged 30 -39 years,37 aged 40 -49 years and 21 ≥50 years old （9 males and 12 females）.Males had high-to-low incidence rate of HUA in group A,C,B and D.The result of Pearson correlation analysis showed that BUA level were positively correlated with ages,tenderness scores and VAS of main pain sites in patients with MPS（r =0.425, P =0.016;r =0.496,P =0.004;r =0.402,P =0.028）.Conclusion：The incidence rate of HUA is high in patients with MPS,and the BUA level is positively correlated with ages and the degree of pain and tenderness.