二丁酰环磷腺苷钙联合生脉、黄芪注射液治疗慢性心力衰竭的临床效果

Clinical Observation of Caleium Dibulyryl Cyclic Adenosine Monophate and Sheng-mai,Astragalus Injection in treatment of Chronic Heart Failure

目的观察二丁酰环磷腺苷钙联合生脉、黄芪注射液治疗慢性心力衰竭(chronic heart failure,CHF)的临床效果。方法将80例CHF随机分为研究组和对照组,每组40例。对照组予强心、利尿等常规抗心力衰竭治疗,研究组在常规治疗基础上予二丁酰环磷腺苷钙联合生脉、黄芪注射液治疗。疗程均为2周,疗程结束后比较两组疗效。结果研究组、对照组治疗后心功能均有所改善,总有效率分别为95.0%、80.0%,差异有统计学意义(P<0.05);6 min步行试验总有效率分别为87.5%、75.0%,差异有统计学意义(P<0.05)。治疗后两组N末端B型利钠肽前体(NT-pro BNP)水平均有所下降(P<0.01),研究组较对照组下降更为明显(P<0.05);两组左心室舒张末内径(LVEDD)较治疗前均缩小(P<0.05),左心室射血分数(LVEF)、心输出量(CO)均较治疗前提高(P<0.05),研究组上述指标改善优于对照组(P<0.01)。两组治疗中均未发现明显不良反应。结论二丁酰环磷腺苷钙联合生脉、黄芪注射液治疗CHF能更好地改善心功能,提高患者的生活质量。

Objective To observe the clinical effect of Caleium dibulyryl cyclic adenosine monophate and Sheng-mai injection and Astragalus injection to treat chronic heart failure （ CHF） . Methods 80 patients with CHF were randomly divid-ed into two groups （n=40）; control group was given conventional heart failure （cardiac, diuretic） treatment. Study group （n=40）, in addition to the conventional therapy, was given the Caleium dibulyryl cyclic adenosine monophate Sheng-mai in-jection, and Astragalus injection. The course of treatment of the two groups was two weeks. The efficacy of treatment was com-pared. Results The heart function of the two groups after treatment was improved. The total efficiency of the study group was 95. 0% while the control group was 80. 0%（P〈0. 05）. The result of 6min walk test：The total efficiency of the study group was 87. 5%, while the control group was 75. 0%. The difference was statistically significant（P〈0. 05）. The comparison of plasma NT-pro BNP levels： After 2 weeks of treatment, the NT-pro BNP levels of the two groups were decreased, and the study group was more significantly than control group. The difference was statistically significant（P〈0. 05）. After 2 weeks of treatment, the LVEPO of both groups was reduced. The LVEF and CO were improved（P〈0. 05）. The study group was better than the control group and the difference was statistically significant（P〈0. 01）. The two groups were not found with signifi-cant adverse reactions. Conclusion Caleium dibulyryl cyclic adenosine monophate and Sheng-mai injection and Astragalus injection in treatment of chronic heart failure is safe and effective in improving heart function with good prognosis and better quality of life.